Tetrahydroharmine

Tetrahydroharmine (THH) is a fluorescent indole alkaloid that occurs in the tropical liana species Banisteriopsis caapi. THH weakly inhibits serotonin reuptake. Tetrahydroharmine (THH) is a fluorescent indole alkaloid that occurs in the tropical liana species Banisteriopsis caapi. THH weakly inhibits serotonin reuptake. THH does not inhibit monoamine oxidase B, however two other harmala alkaloids in B. caapi, harmaline and harmine, are reversible inhibitors of monoamine oxidase A. While THH may not play a significant role in the inhibition of MAO it may contribute psychoactivity indirectly by inhibiting the uptake of Serotonin in platelets and presynaptic neurons . Harmala alkaloids are considered Schedule 9 prohibited substances under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.