Calmodulin-binding proteins are, as their name implies, proteins which bind calmodulin. Calmodulin can bind to a variety of proteins through a two-step binding mechanism 'conformational and mutually induced fit', where typically two domains of calmodulin wrap around an emerging helical calmodulin binding domain from the target protein. Calmodulin-binding proteins are, as their name implies, proteins which bind calmodulin. Calmodulin can bind to a variety of proteins through a two-step binding mechanism 'conformational and mutually induced fit', where typically two domains of calmodulin wrap around an emerging helical calmodulin binding domain from the target protein.