Baylisascaris procyonis, common name raccoon roundworm, is a roundworm nematode, found ubiquitously in raccoons, the definitive hosts. It is named after H. A. Baylis, who studied them in the 1920s–30s, and Greek askaris (intestinal worm). Baylisascaris larvae in paratenic hosts can migrate, causing visceral larva migrans (VLM). Baylisascariasis as the zoonotic infection of humans is rare, though extremely dangerous due to the ability of the parasite's larvae to migrate into brain tissue and cause damage. Concern for human infection has been increasing over the years due to urbanization of rural areas resulting in the increase in proximity and potential human interaction with raccoons. Baylisascaris procyonis, common name raccoon roundworm, is a roundworm nematode, found ubiquitously in raccoons, the definitive hosts. It is named after H. A. Baylis, who studied them in the 1920s–30s, and Greek askaris (intestinal worm). Baylisascaris larvae in paratenic hosts can migrate, causing visceral larva migrans (VLM). Baylisascariasis as the zoonotic infection of humans is rare, though extremely dangerous due to the ability of the parasite's larvae to migrate into brain tissue and cause damage. Concern for human infection has been increasing over the years due to urbanization of rural areas resulting in the increase in proximity and potential human interaction with raccoons. The potential for human infection was noted in 1969 by Paul C. Beaver, who studied infected mice, and the first case was reported 15 years later. Human infection with B. procyonis has been relatively rare, with about 30 cases reported since 1980. However, disease caused by this parasite can be extremely dangerous, causing death or severe symptoms. Reported disease has primarily afflicted children and almost all cases were a result of the ingestion of contaminated soil or feces. Even with treatment, prognosis is poor and patients in nearly all cases experience permanent neurological damage. Infection of the eyes may result in permanent visual damage and loss. The common antihelmintic medicines are able to treat adult worms living in the intestines, but are less effective against migrating larvae. Aggressive and early treatment with corticosteroids and albendazole have in a few instances resulted in complete recoveries. It is possible that human infection is more common than diagnosed and most cases do not reach a clinical stage. Antibodies to B. procyonis have been found in otherwise healthy individuals, suggesting subclinical infections. In North America, B. procyonis infection rates in raccoons are very high, being found in around 70% of adult raccoons and 90% of juvenile raccoons. Transmission occurs similarly to other roundworm species, through the fecal-oral route. Eggs are produced by the worm while in the intestine, and the released eggs will mature to an infective state externally in the soil. When an infected egg is ingested, the larvae will hatch and enter the intestine. Transmission of B. procyonis may also occur through the ingestion of larvae found in infected tissue. An adult worm lives and reproduces in the intestine of its definitive host, the raccoon. The female worm can produce between 115,000–179,000 eggs per day. Eggs are excreted along with feces, and become infective in the soil after 2–4 weeks. If ingested by another raccoon, the life cycle repeats. However, if these eggs are ingested by a paratenic host (small mammals, birds) the larvae of B. procyonis will penetrate the gut wall of the host and migrate into tissues. Larvae tend to migrate to the brain, cause damage, and affect the behaviour of the intermediate host, making it an easier prey for raccoons. Reproduction does not occur in these paratenic hosts; however, if a raccoon preys on an infected paratenic host, the encysted larvae can become adults in the raccoon and the cycle resumes. Laboratory and clinical diagnosis can be challenging: there is no commercially available serologic test in the United States, and although identification of larvae in tissue or specimens is confirmatory, this is not always possible or practical. Diagnosis of B. procyonis is through identification of larvae in tissue examination. Diagnosis requires forehand knowledge along with understanding and recognition of larval morphologic characteristics, including ability to distinguish between a number of possible other parasites, including Toxocara canis, Toxocara cati, Ascaris lumbricoides, and among species of Gnathostoma, Angiostrongylus, and Ancylostoma. Distinguishing features of B. procyonis larvae in tissue are its relatively large size (60 μ) and prominent single lateral alae. Sometimes serologic testing is used as supportive evidence, although no commercial serologic test is currently available.Other diagnosis methods include: brain biopsy, neuroimaging, electroencephalography, differential diagnoses among other laboratory tests. Human Baylisascariasis is under-recognized, as the knowledge of the clinical illness is still a bit unclear. This could be because of the difficulty of diagnosing the illness. As small numbers of larvae can cause severe disease, and larvae occur randomly in tissue, a biopsy usually fails to include larvae and therefore leads to negative results. The identification of the morphologic characteristics takes practice and experience and may not be accurately recognized or could be misidentified. The fact that no commercial serologic test exists for the diagnosis of B. procyonis infection makes the diagnosis and treatment more difficult. Educating the public about the dangers of contact with raccoons or their feces is the most important preventive step.Parents should encourage their children to practice good hygiene; Hand-washing after outdoor play or contact with animals is very important. Fences can be used to prevent raccoons from visiting homes, garbage, or yards for food. Keeping raccoons as pets is strongly discouraged. Raccoon latrines in and around homes should be checked for and cleaned as soon as possible. Boiling water, steam-cleaning, flaming, or fire are highly effective and are easily accessible means to decontaminate household things or areas. Materials contaminated by B.procyonis should be incinerated. Contaminated areas can be cleaned with a xylene-ethanol mixture. Common chemical disinfectants are not effective against B.procyonis eggs. Disinfectants like 20% bleach (1% sodium hypochlorite) wash away the eggs but do not kill them. Since treatment is not very effective, the best way to escape this parasite is to practice the prevention methods.