ADAM19

872811492ENSG00000135074ENSMUSG00000011256Q9H013O35674NM_023038NM_033274NM_001291890NM_001291891NM_009616NM_001311209NP_150377NP_001278819NP_001278820NP_001298138NP_033746ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene. ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants. ADAM19 has been shown to interact with ABI2.