WWTR1

WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1 gene.2593797064ENSG00000018408ENSMUSG00000027803Q9GZV5Q9EPK5NM_001168278NM_001168280NM_015472NM_001348362NM_001168281NM_133784NP_001161750NP_001161752NP_056287NP_001335291NP_001161753NP_598545WWTR1 It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/LATS2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADs and has a key role in coupling them to the transcriptional machinery such as the mediator complex.