EPHA8

1UCV, 1X5L, 3KUL204613842ENSG00000070886ENSMUSG00000028661P29322O09127NM_001006943NM_020526NM_007939NP_001006944NP_065387NP_031965Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.1ucv: Sterile alpha motif (SAM) domain of ephrin type-A receptor 81x5l: Solution structure of the second fn3 domain of Eph receptor A8 protein Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. EPHA8 has been shown to interact with FYN.