The subiculum (Latin for 'support') is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.Basic circuit of the hippocampus The subiculum (Latin for 'support') is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper. The subicular complex comprises a set of related structures including (as well as subiculum proper) prosubiculum, presubiculum, postsubiculum and parasubiculum. The Subiculum got its name from Karl Friedrich Burdach in his three-volume work Vom Bau und Leben des Gehirns (Vol. 2, §199). He originally named it subiculum cornu ammonis and so associated it with the rest of the hippocampal subfields. It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, lateral hypothalamus, nucleus reuniens, mammillary nuclei, entorhinal cortex and amygdala. The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus. Four component areas have been described: parasubiculum (adjacent to the parahippocampal gyrus), presubiculum, postsubiculum, and prosubiculum. The parasubiculum contains grid cells, which are neurons responsive to movements in particular directions over particular distances. The presubiculum is part of the posterior cortex corresponding to Brodmann's area 27, and forms part of the cortical input to the entorhinal-hippocampal spatial/memory system. The dorsal part of the presubiculum is more commonly known as the postsubiculum and is of interest because it contains head direction cells, which are responsive to the facing direction of the head.