RUNX1T1

1WQ6, 2DJ8, 2H7B, 2KYG, 2OD1, 2ODD, 2PP4, 4JOL86212395ENSG00000079102ENSMUSG00000006586Q06455Q61909NM_001198630NM_001198631NM_001198632NM_001198633NM_001198634NM_001198679NM_004349NM_175634NM_175635NM_175636NM_001111026NM_001111027NM_009822NP_001185559NP_001185560NP_001185561NP_001185562NP_001185563NP_001185608NP_004340NP_783552NP_783553NP_783554NP_783553.1NP_783554.1NP_001104496NP_001104497NP_033952Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.1wq6: The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity2dj8: Solution Structure of zf-MYND Domain of Protein CBFA2TI (Protein MTG8)2h7b: Solution structure of the eTAFH domain from the human leukemia-associated fusion protein AML1-ETO Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. RUNX1T1 has been shown to interact with: