In philosophy of science, strong inference is a model of scientific inquiry that emphasizes the need for alternative hypotheses, rather than a single hypothesis to avoid confirmation bias.The temptation to misinterpret results that contradict the desired hypothesis is probably irresistible. In philosophy of science, strong inference is a model of scientific inquiry that emphasizes the need for alternative hypotheses, rather than a single hypothesis to avoid confirmation bias. The term 'strong inference' was coined by John R. Platt, a biophysicist at the University of Chicago. Platt notes that some fields, such as molecular biology and high-energy physics, seem to adhere strongly to strong inference, with very beneficial results for the rate of progress in those fields. The problem with single hypotheses, confirmation bias, was aptly described by Thomas Chrowder Chamberlin in 1897: