GRIN2A

3NFL, 5H8Q, 5H8H, 5H8N, 5H8F, 5I2N, 5I2K, 5KDT, 5KCJ290314811ENSG00000183454ENSMUSG00000059003Q12879P35436NM_000833NM_001134407NM_001134408NM_008170NP_000824NP_001127879NP_001127880NP_032196Glutamate receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.2a5s: Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate2a5t: Crystal Structure Of The NR1/NR2A ligand-binding cores complex Glutamate receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene. N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). Variants of the gene are associated with the protective effect of coffee on Parkinson's disease. Mutations in GRIN2A are associated to refractory epilepsy. Whole exome/genome sequencing has led to the discovery of an association between mutations in GRIN2A and a wide variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia. GRIN2A has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.