Thyroid hormone receptor beta

1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1706821834ENSG00000151090ENSMUSG00000021779P10828P37242NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001113417NM_009380NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001106888NP_033406Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.1bsx: STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS1n46: CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC1nax: Thyroid receptor beta1 in complex with a beta-selective ligand1nq0: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD1nq1: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD1nq2: Two RTH Mutants with Impaired Hormone Binding1nuo: Two RTH Mutants with Impaired Hormone Binding1q4x: Crystal Structure of Human Thyroid Hormone Receptor beta LBD in complex with specific agonist GC-241r6g: Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound1xzx: Thyroxine-Thyroid Hormone Receptor Interactions1y0x: Thyroxine-Thyroid Hormone Receptor Interactions2h6w:2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far. Thyroid hormone receptor beta has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.