PRKCD

2YUU, 1YRK558018753ENSG00000163932ENSMUSG00000021948Q05655P28867NM_001354679NM_001354680NM_011103NM_001310682NP_001341608NP_001341609NP_001297611NP_035233Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene.1bdy: C2 DOMAIN FROM PROTEIN KINASE C DELTA1ptq: PROTEIN KINASE C DELTA CYS2 DOMAIN1ptr: PROTEIN KINASE C DELTA CYS2 DOMAIN COMPLEXED WITH PHORBOL-13-ACETATE1yrk: The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Protein kinase C delta is also regulated by phosphorylation on various serine/threonine (e.g. T50, T141, S304, T451, T505, S506, T507, S643, S664) and tyrosine residues including Y311 (by SRC). PRKCD has been shown to interact with: