Lecithin retinol acyltransferase

4Q95922779235ENSG00000121207ENSMUSG00000028003O95237Q9JI60NM_001301645NM_004744NM_023624NP_001288574NP_004735NP_076113Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene. Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene. Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.