MIXL1

Mixl1 is a paired-type homeobox transcription factor weighing 27 kDa with 232 amino acids. Mixl1 transcription factor preferentially binds to the DNA sequence TAAT on the Mix gene. Mixl1 is part of the Mix/Bix family of transcription factors, with Mixl1 being the only member identified in humans. The Xenopus Mix gene and human Mix genese are homologues. Mixl1 is functionally similar to the Xenopus Mix.1. Mixl1 is a paired-type homeobox transcription factor weighing 27 kDa with 232 amino acids. Mixl1 transcription factor preferentially binds to the DNA sequence TAAT on the Mix gene. Mixl1 is part of the Mix/Bix family of transcription factors, with Mixl1 being the only member identified in humans. The Xenopus Mix gene and human Mix genese are homologues. Mixl1 is functionally similar to the Xenopus Mix.1. Mixl1 is transiently expressed in the primitive streak of the gastrulating embryo, between embryonic day (E) 12 through E.19. Its expression is restricted to embryonic mesoderm precursors.