NLRP7

2KM6199713n/aENSG00000277776ENSG00000277786ENSG00000275483ENSG00000277071ENSG00000274571n/aQ8WX94n/aNM_001127255NM_139176NM_206828n/aNP_001120727NP_631915NP_996611n/aNACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene. NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene. NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.