USF1

1AN4739122278ENSG00000158773ENSMUSG00000026641P22415Q61069NM_207005NM_001276373NM_007122NM_009480NM_001305676NM_001305677NM_001305678NP_001263302NP_009053NP_996888NP_001292605NP_001292606NP_001292607NP_033506Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.1an4: STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene. This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. A study of mice suggested reduced USF1 levels increases metabolism in brown fat. USF1 (human gene) has been shown to interact with USF2, FOSL1 and GTF2I.