KLF6

131623849ENSG00000067082ENSMUSG00000000078Q99612O08584Q8BPQ2NM_001008490NM_001160124NM_001160125NM_001300NM_011803NP_001153596NP_001153597NP_001291NP_035933Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene. This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene. KLF6 has been shown to interact with Sp1 transcription factor. This article incorporates text from the United States National Library of Medicine, which is in the public domain.