Feline sarcoma oncogene

1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93224214159ENSG00000182511ENSMUSG00000053158P07332P16879NM_001143783NM_001143784NM_001143785NM_002005NM_010194NP_001137255NP_001137256NP_001137257NP_001996NP_034324Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.1wqu: Solution structure of the human FES SH2 domain2dcr: Fully automated solution structure determination of the Fes SH2 domain Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified. Feline sarcoma oncogene has been shown to interact with BCAR1 and BCR gene.