Ribosomal protein s6

Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, mouse model studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis. Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, mouse model studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis. Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function. Pathways leading to the induction of human rpS6 phosphoryation been found to enhance Interleukin 8 IL-8 protein synthesis. This mechanism is dependent on A/U-rich proximal seqeunces (APS) found in the 3'UTR if IL-8 immediately after the stop codon.