Interleukin 32

9235n/aENSG00000008517n/aP24001n/aNM_001012636NM_001012718NM_001308078NM_004221n/aNP_001012654NP_001012736NP_001295007NP_004212NP_001356516NP_001356517NP_001356518NP_001356519NP_001356520NP_001356521NP_001356522NP_001356524NP_001356525n/aInterleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene. Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2. IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton. This article incorporates text from the United States National Library of Medicine, which is in the public domain.