SOS1

1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2II0665420662ENSG00000115904ENSMUSG00000024241Q07889Q62245NM_005633NM_009231NP_005624NP_033257Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.1awe: HUMAN SOS1 PLECKSTRIN HOMOLOGY (PH) DOMAIN, NMR, 20 STRUCTURES1bkd: COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-11dbh: DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS11nvu: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS1nvv: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS1nvw: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS1nvx: Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS1pms: PLECKSTRIN HOMOLOGY DOMAIN OF SON OF SEVENLESS 1 (SOS1) WITH GLYCINE-SERINE ADDED TO THE N-TERMINUS, NMR, 20 STRUCTURES1q9c: Crystal Structure of the Histone domain of Son of Sevenless1xd2: Crystal Structure of a ternary Ras:SOS:Ras*GDP complex1xd4: Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)1xdv: Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang.2ii0: Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange. Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes. activators of the MAP kinase pathway. SOS1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.