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Entamoeba

Entamoeba is a genus of Amoebozoa found as internal parasites or commensals of animals. In 1875, Fedor Lösch described the first proven case of amoebic dysentery in St. Petersburg, Russia. He referred to the amoeba he observed microscopically as Amoeba coli; however, it is not clear whether he was using this as a descriptive term or intended it as a formal taxonomic name. The genus Entamoeba was defined by Casagrandi and Barbagallo for the species Entamoeba coli, which is known to be a commensal organism. Lösch's organism was renamed Entamoeba histolytica by Fritz Schaudinn in 1903; he later died, in 1906, from a self-inflicted infection when studying this amoeba. For a time during the first half of the 20th century the entire genus Entamoeba was transferred to Endamoeba, a genus of amoebas infecting invertebrates about which little is known. This move was reversed by the International Commission on Zoological Nomenclature in the late 1950s, and Entamoeba has stayed 'stable' ever since. Several species are found in humans and animals. Entamoeba histolytica is the pathogen responsible for invasive 'amoebiasis' (which includes amoebic dysentery and amoebic liver abscesses). Others such as Entamoeba coli (not to be confused with Escherichia coli) and Entamoeba dispar are harmless. With the exception of Entamoeba gingivalis, which lives in the mouth, and E. moshkovskii, which is frequently isolated from river and lake sediments, all Entamoeba species are found in the intestines of the animals they infect. Entamoeba invadens is a species that can cause a disease similar to E. histolytica but in reptiles. In contrast to other species, E. invadens forms cysts in vitro in the absence of bacteria and is used as a model system to study this aspect of the life cycle. Many other species of Entamoeba have been described, and it is likely that many others remain to be found. Entamoeba cells are small, with a single nucleus and typically a single lobose pseudopod taking the form of a clear anterior bulge. They have a simple life cycle. The trophozoite (feeding-dividing form) is approximately 10-20 μm in diameter and feeds primarily on bacteria. It divides by simple binary fission to form two smaller daughter cells. Almost all species form cysts, the stage involved in transmission (the exception is Entamoeba gingivalis). Depending on the species, these can have one, four or eight nuclei and are variable in size; these characteristics help in species identification. Entamoeba belongs to the Archamoebae, which like many other anaerobic eukaryotes lack mitochondria. This group also includes Endolimax and Iodamoeba, which also live in animal intestines and are similar in appearance to Entamoeba, although this may partly be due to convergence. Also in this group are the free-living amoebo-flagellates of the genus Mastigamoeba and related genera. Certain other genera of symbiotic amoebae, such as Endamoeba, might prove to be synonyms of Entamoeba but this is still unclear. Studying Entamoeba invadens, David Biron of the Weizmann Institute of Science and coworkers found that about one third of the cells are unable to separate unaided and recruit a neighboring amoeba (dubbed the 'midwife') to complete the fission. He writes: They also reported a similar behavior in Dictyostelium. Since E. histolytica does not form cysts in the absence of bacteria, E. invadens has become used as a model for encystation studies as it will form cysts under axenic growth conditions, which simplifies analysis. After inducing encystation in E. invadens, DNA replication increases initially and then slows down. On completion of encystation, predominantly tetra-nucleate cysts are formed along with some uni-, bi- and tri-nucleate cysts.

[ "Parasite hosting", "Entamoeba histolytica", "Protozoa", "Entamoebas", "Entamoeba histolytica/Entamoeba dispar", "Entamoeba chattoni", "entamoeba struthionis", "Entamoeba bovis" ]
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