ZWINT

1113052696ENSG00000122952ENSMUSG00000019923O95229Q9CQU5NM_001005413NM_001005414NM_007057NM_032997NM_001293683NM_001293684NM_025635NP_001005413NP_008988NP_127490NP_001280612NP_001280613NP_079911ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. ZWINT has been shown to interact with MIS12.ZWINT has also been shown to interact with RAB3C