Dystrobrevin is a protein that binds to dystrophin in the costamere of skeletal muscle cells. There are at least two isoforms of dystrobrevin in man, α-dystrobrevin and β-dystrobrevin. Dystrobrevin is a protein that binds to dystrophin in the costamere of skeletal muscle cells. There are at least two isoforms of dystrobrevin in man, α-dystrobrevin and β-dystrobrevin.