Rudenko Lg

Institute of Experimental Medicine

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Grigor'eva Ep

Naĭkhin An

Rekstin Ar

Donina Sa

Yulia Desheva

Czech Academy of Sciences, Institute of Experimental Medicine

Zykov Mp

Research Institute of Influenza

Klimov Ai

Burtseva Ei

Ministry of Health of the Russian Federation

Slepushkin An

Russian Academy of Sciences

Aleksandrova Gi

Cooperative Institutions

Russian Academy of Sciences

Academy of Medical Sciences

Research Institute of Influenza

Institute of Experimental Medicine

Czech Academy of Sciences, Institute of Experimental Medicine

Ministry of Health

Ministry of Health of the Russian Federation

National Institutes of Health

D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences

Institute of Virology of the Slovak Academy of Sciences

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[Homologous and heterologous antibody induction in influenzal infection and immunization].

PubMed (1977)

Rudenko Lg Rafaél'skaia Ti Nesterenko Ls

Serological examinations were carried out in 72 patients with influenza and 384 volunteers immunized with a vaccine from different strains of influenza A virus. A high level of antibody (greater than 1:64) was found to protect against influenza infection by a homologous strain as well as strains with certain immunologic affinity in the main virus structures, hemagglutinin and neuraminidase.

Heterologous

Strain (injury)

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[Immune response of elderly persons depending on the number of annual seasonal immunizations of live and inactivated influenza vaccines].

PubMed (1998)

Naĭkhin An Rudenko Lg Nancy H. Arden Jonathan D. Katz Grigor'eva Ep

A total of 159 subjects aged 65-87 years were immunized with live cold-adapted reassortant influenza vaccine (CRIV), inactivated influenza vaccine (IIV), and with both vaccines (CRIV + IIV) one year, two and three years running. The frequency and intensity of accumulation of postvaccinal secretory and humoral antibodies in elderly subjects depend on the scheme of immunization and history of vaccinations. Combination of the two vaccines effectively stimulated both components of immunity and ensured a longer persistence of postvaccinal antibodies in high concentrations. Immunization with CRIV + IIV for three years resulted in a gradual increase of the intensity of prevaccination secretory and humoral immunity. Before the third seasonal immunization the majority (63-75%) of vaccinees had antibodies in protective titers.

Humoral immunity

Inactivated vaccine

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[Experience in using inactivated influenza vaccine with persons at "high risk"].

PubMed (1979)

Rudenko Lg Zoshchenko NIa Zykov Mp Fridman Ea

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[Local antibody immune responses in influenza patients and persons vaccinated with seasonal, pre-pandemic, and pandemic live attenuated influenza vaccines].

PubMed (2013)

Donina Sa Galina Petukhova Koren'kov Da Grigor'eva Ep Kuznetsova Sa

Mucosal immunity is one of the most important factors of human anti-influenza defense. The data about local immune responses in influenza A (H3N2) patients and in persons vaccinated within 2000-2009 with different seasonal LAIVs, A (H1N1)pdm2009 LAIV, and A (H5N2) LAIV are discussed. The influenza infection resulted in the larger quantities of local IgA and IgG conversions than seasonal LAIV vaccination. 56% of young (18-21 y.o.) persons had high titers (> or = 1:64) of IgA to A (H1N1)pdm2009 virus before its circulation. 19% of persons had anti A (H5N2) IgA before vaccination. Two-fold vaccination with A (H1N1) pdm2009 and A (H5N2) LAIVs resulted in local antibody conversions in 54% and 27% of volunteers, respectively. Both these vaccines increased local IgA avidity. The number of antibody conversions after vaccination with seasonal LAIVs was in inverse dependence on their titers before vaccination. These results make it possible to conclude that the intensity of local antibody immune response to any LAIV depends on the state of local immunological memory, particularly on the presence of the crossreactive antibody-secreting B cells.

Avidity

Pandemic

Antibody titer

Seasonal influenza

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The inoculation properties of live recombinant influenza vaccine types A and B used separately and jointly in children 3 to 14

Problems of Virology (1991)

Rudenko Lg Arlen Patricia Gómez Ramírez Mario Barro Gushchina Mi Armanda Re

The reactogenicity and immunizing activity of vaccine influenza virus A (H1N1) and B strains used as mono- and bi-preparations in children of 3 to 14 years was studied. No increased reactogenicity after the use of bivaccine was observed in the children. Febrile reactions as well as 9 other clinical symptoms which could indicate the reactogenicity of the vaccines were identical for mono- and bivaccine and corresponded to the requirements of the technical documents for the vaccine. The optimal conditions for the evaluation of the immunogenicity of the B component by HI test were developed, and the necessity of using additionally the enzyme immunoassay for this purpose is substantiated. The above method demonstrated that the immunogenicity of the live influenza type A and B vaccine was high in children. No significant inhibition of immunological parameters was observed when the two viruses were combined in the bivaccine.

Reactogenicity

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[B-cell and cytotoxic lymphocyte immune response to virulent, attenuated and reassortant influenza viruses].

PubMed (2002)

Rekstin Ar Naĭkhin An Barantseva Ib Rudenko Lg

The quantitative estimation of the production of the virus specific IgA-, IgM-, IgG1, IgG2a, IgG2b and IgG3-antibody secreting B-cells (ASC) and extent of the immune response of the cytotoxic T-lymphocytes was carried out in mice after primary and secondary immunization with the parental cold adapted (ca) virulent epidemic wild-type (wt) master strain viruses and their reassortant variant (RV) with the incorporated in their genom different genes from ca master strain. The chick embryo derived ca master strain virus A/Len/134/47/57 (H2N2) reduced or eliminated the viral potency to induce the primary B-cellular response. Reassortant incorporation of wt derived HA and NA genes into the ca virus genome restored the virus immunogenic activity concerning the ASC production, but at the lower level than parental virulent virus. Reassortance of the viruses according to generally accepted genom formula 6/2 was associated with decrement of the functional activity of the cytotoxic T-lymphocytes memory and of the primary immune response especially. The data obtain demonstrate the necessity for the control of the immunogenicity of the reassortant viruses at the cloning stage.

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[The formation of an immune response in volunteers inoculated with a live recombinant influenza vaccine].

PubMed (1991)

Vorob'ev Kv Rudenko Lg Islamova It Grigor'eva Ep Andrej Egorov

The capacity of a live influenza vaccine (LIV) to stimulate cytotoxic cells (ADCMC and NK) was studied in 49 volunteers and 56 patients with influenza. Experimental batches of LIV from influenza A and B viruses prepared by genetic recombination on the basis of cold-adapted attenuation donors were used. Type A and B LIV were shown to stimulate the cytotoxic cell-mediated and humoral immunity; the intensity of immune response, however, depended on the molecular genetic characteristics of the vaccine (genome structure, properties of the donor of attenuation), its biological activity and capacity of reproduction in tissues.

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[Humoral and local immune response to the influenza vaccine in people of old and young ages].

PubMed (2003)

Barantseva Ib Naĭkhin An Donina Sa Stepanova La Rekstin Ar

The specific features of the humoral and local immune responses to influenza vaccines were comparatively studied in people of different age groups. A total of 79 elderly people (aged 67-89) and 80 young people (aged 18-27) were immunized according to one of the four schemes: live cold-adapted reassortant trivalent influenza vaccine (LIV), administered intranasally; inactivated split trivalent influenza vaccine (IIV), administered parenterally; a combination of both above vaccines; and placebo. IIV was found, as compared to LIV, to stimulate more effectively the production of circulating antihaemagglutinins as well as of IgG,-, Ig1-, and Ig3-AT in young persons, while LIV has advantages before IIV in stimulating the synthesis of these immunoglobulins in the elderly. LIV has advantages before IIV in stimulating the synthesis of secretory IgA-AT irrespective of an age of the immunized persons. The combined immunization of the elderly by both vaccines increases the quantitative parameters of the humoral and local responses up to the level of intensity observed in young people. The obtained data are indicative of the possibility of correcting the immune response in the high-risk elderly in respect to influenza infection.

Elderly people

Humoral immunity

Age groups

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[Dynamics of the antihemagglutinin level in annual human immunization with inactivated influenza vaccines].

PubMed (1985)

Selivanov Aa Rudenko Lg Zykov Mp

Inactivated influenza vaccines are classified according to the types of antihemagglutinin response after annual revaccination of people with inactivated influenza vaccines carried out for 3 successive years. The results of analysis show that in response to annual revaccination with inactivated vaccine up to 80% of the vaccinees develop no positive changes in antihemagglutinin titres. An experiment using a liver moderately attenuated vaccine after a single immunization with an inactivated vaccine demonstrated that 64.7% vaccinees would not be involved in the epidemic process at all and 11.5% would be involved at the level of asymptomatic infection. The remaining portion (23.8%), also involved in the epidemic process after immunization with inactivated vaccine, apparently requires additional immunological protection. The results of the above study indicate the inefficacy of annual vaccination of the same subjects with the same inactivated influenza vaccine.

Inactivated vaccine

Attenuated vaccine

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[Cross protection in mice immunized with different anti-influenza preparations].

PubMed (1981)

Rudenko Lg Sosunov Av Zykov Mp

Observations in white mice demonstrated the development of resistance to influenza type A virus (H3N2 and H0N1) after vaccination against influenza A (H1N1). The most marked cross protection between these serotypes developed after combined use of inactivated and live moderately attenuated vaccines. The resistance to the homologous influenza A (H1N1) virus after vaccination with different influenza vaccines used by various schedules was approximately similar. The role of common antigens and cellular factors of immunity in the development of cross protection against influenza type A viruses is discussed.

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