Support vector machine (SVM) constructs an optimal hyperplane utilizing a small set of vectors near boundary. The proximal SVM is an extremely simple procedure to generate linear and nonlinear classifier based on proximity to one of two parallel planes that are separated as far as possible. However, when the two-class are very unbalanced, the proximal SVM tends to fit better the class with more samples and has higher error in fewer samples. Further more, this draw back exists in K-category classification by using one-from-the-rest (OFR) separation for each class. To solve the problem, an improved SVM algorithm is presented in this paper. Experimental results show that the novel approach is prior to the proximal SVM.

Statistical classification

10.1109/icciautom.2011.6183968

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[Diffusible signal factor production and virulence expression in deltarpfFxoo, deltarpfCxoo and deltarpfGxoo, the gene deletion mutants of DSF/Rpf signaling proteins of Xanthomonas oryzae pv. oryzae].

PubMed (2010)

Lei Sun Maosen Wu Huamin Chen Chenyang He

To better elucidate the functions of RpfFxoo, RpfCxoo and RpfGxoo, 3 proteins of diffusible signal factor (DSF)-dependent cell-cell signaling system in regulation of virulence expression of Xanthomonas oryzae pv. oryzae (Xoo).Deltarpfxoo, the gene deletion mutants were generated from PXO99(A), the wild-type strain of Xoo via marker-exchanging and DSF biosynthesis and extracellular polysaccharide production and virulence to rice of the mutants were assayed.rpfFxoo,rpfCxoo and rpfGxoo were cloned from the genomic DNA of PXO99(A) and the relative single or double mutants were constructed. Compared to PXO99(A), DSF production was deficient in deltarpfFxoo, deltarpfFCxoo and deltarpfFGxoo, while DSF was overproduced in deltarpfCxoo and reduced in deltarpfGxoo. DSF production of deltarpfFxcc, deltarpfCxcc and deltarpfGxcc, the mutants of X. campestris pv. campestris can be restored as XC1, the wild-type strain by in trans complementation of rpfFxoo, rpfCxoo and rpfGxoo. All the mutants except deltarpfFxoo were remarkably deficient in production All the mutants significantly exhibited the reduced bacterial virulence to rice. of extracellular polysaccharide.DSF signaling proteins RpfFxoo, RpfCxoo and RpfGxoo might function in regulation of DSF biogenesis and EPS production and bacterial virulence.

Virulence factor

Source

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Enhancing Predictions of N2o Emissions During Manure Composting Using Model-Agnostic Meta-Learning (Maml)

Shuai Shi Jiaxin Bao Zhiheng Guo Yue Han Yonghui Xu

Composting is a promising strategy for manure treatment that recycles organic waste. However, nitrous oxide (N2O) is generated during the composting process. This causes nitrogen loss and pollution, and contributes to global warming which is a problem of global concern. This study employed the model-agnostic meta-learning (MAML) to enhance the performance of N2O emissions prediction during manure composting based on machine learning. The highest R2 and lowest root mean squared error (RMSE) values achieved were 0.939 and 18.42 mg d-1, respectively, comparing with five contrast models based on machine learning. Feature analysis showed that moisture content of co-composting material and ammonia concentration during composting process were the two most significant features affecting N2O emissions. This study serves as proof of the application of the MAML method during waste management, further giving new insights into the effects of manure material properties and composting process data on N2O emissions.

Metamodeling

10.2139/ssrn.4625505

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Nursing of a patient with insomnia treated by auricular acupoint sticking and pressing combined with stellate ganglion block

Chinese Journal of Integrative Nursing (2023)

Cuiying WANG Lei Sun Ling TANG Shilei CHANG Tianhao LIU

10.55111/j.issn2709-1961.202212079

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Unveiling Mechanisms of Chemotherapy Resistance: Targeting FOXP1 Phase Separation in Small Cell Lung Cancer

Research Square (Research Square) (2024)

Linlang Guo Yichun Tang Yuchun Niu Yueyang Hu Yi Chen

Abstract Our study elucidates the role of FOXP1 in chemoresistance in SCLC. FOXP1 enhances chemoresistance by regulating SP8 expression through its super-enhancer (SP8-SE), with SP8 mediating resistance via the homologous recombination repair (HRR) pathway. We also discovered that FOXP1 forms punctate nuclear structures indicative of liquid-liquid phase separation ¹, crucial for its transcriptional regulation. Targeting the FOXP1-SP8-HR axis with BRD4 and PARP inhibitors showed synergistic effects in reducing tumor growth in vitro and in patient-derived xenograft models. These findings identify FOXP1 as a critical mediator and marker of chemoresistance in SCLC, providing a foundation for developing targeted therapies to overcome this resistance.

10.21203/rs.3.rs-4876919/v1

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SNPs detected in the yak MC4R gene and their association with growth traits

animal (2015)

Xin Cai TserangDonko Mipam Fangfang Zhao Lei Sun

MC4R (melanocortin 4 receptor) is expressed in the appetite-regulating areas of the brain and takes part in leptin signaling pathways. Sequencing of the coding region of the MC4R gene for 354 yaks identified the following five single nucleotide polymorphisms (SNPs): SNP1 (273C>T), SNP2 (321 G>T), SNP3 (864 C>A), SNP4 (1069G>C) and SNP5 (1206 G>C). SNP1, SNP2 and SNP3 were synonymous mutations, whereas SNP4 and SNP5 were missense mutations resulting in amino acid substitutions (V286L and R331S). Pairwise linkage disequilibrium (LD) analysis indicated that two pairs of SNPs, SNP2 and SNP5 (r(2)=0.81027) and SNP4 and SNP5 (r(2)=0.53816), exhibited higher degrees of LD. CC genotype of SNP4, CGACG and CTCCC haplotypes for all SNPs were associated with increased BW of animals that were 18 months old and with the average daily gain. The secondary structure and transmembrane region prediction of the yak MC4R protein suggested that SNP4 was correlated with influential changes in the seventh transmembrane domain of the MC4R protein and with the functional deterioration or even incapacitation of MC4R, which may contribute to the increased feed intake, BW and average daily gain of the yaks with CC genotypes. The data from this study suggested that 1069G>C SNP of the MC4R gene could be used in marker-assisted selection of growth traits in the Maiwa yak breed.

Linkage Disequilibrium

SNP

Melanocortin 4 receptor

10.1017/s1751731115000397

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Two-dimensional covalent organic skeletons COF-C4N anchored by different metals for bifunctional catalysts for water decomposition

Computational Materials Science (2024)

Malik Nasrulla Chao’en Li Lei Sun Jili Wen Yanhua Zhang

10.1016/j.commatsci.2024.113452

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Identification of a biocontrol agent Bacillus vallismortis BV23 and assessment of effects of its metabolites on Fusarium graminearum causing corn stalk rot

Biocontrol Science and Technology (2018)

Yonggang Li Ruiting Wang Jinxin Liu Lankun Xu Pingsheng Ji

Corn stalk rot, caused by Fusarium graminearum, is one of the most destructive diseases of maize in many regions of the world. A bacterial strain BV23 was isolated from corn rhizosphere that reduced corn stalk rot significantly in greenhouse studies in 2016 and 2017. BV23 was identified as Bacillus vallismortis, which showed antagonistic effects against a number of fungal pathogens, including F. graminearum, Rhizoctonia solani, Athelia rolfsii, and Thanatephorus cucumeris. BV23 had the greatest fungistatic effect on F. graminearum, inhibiting mycelial growth by 66.2%, conidial germination by 90.1%, and conidial production by 86.7%. The probable antifungal mechanism was assessed by examining the morphology and ultrastructure of F. graminearum hyphae. Treatment by BV23 culture supernatant resulted in coarser hyphae, induced cytoplasmic granulation, and increased cell membrane permeability of F. graminearum, causing cytoplasm leakage. These effects became increasingly obvious with increasing concentration (1%, 5% and 10%). Furthermore, the antifungal active substances were sensitive to heat.

Stalk

Rhizoctonia

10.1080/09583157.2018.1548575

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Citations (20)