Objective:The aim of this study is to investigate the pathological features, treatment and prognosis of sarcomatoid carcinoma of head and neck. Methods:The clinical data of 17 patients with sarcomatoid carcinoma of the head and neck treated in the First Affiliated Hospital of Zhengzhou University from September 2013 to September 2020 were retrospectively analyzed, and the pathological characteristics, treatment and follow-up were summarized. Kaplan-Meier method was used to calculate the overall survival rate. Results:The histopathological examination of all patients showed the coexistence of cancer components and sarcoma components, and there was a transitional transition area between them. In terms of treatment, 12 of the 17 patients received surgical treatment, and 5 patients received palliative treatment because they could not tolerate surgery or distant metastasis; The cumulative 1-year, 3-year and 5-year survival rates of 17 patients with head and neck sarcomatoid carcinoma calculated by Kaplan-Meier method were 64.7%, 26.5%, and 13.2%, respectively. Conclusion:Pathological examination of head and neck sarcomatoid carcinoma is the gold standard for diagnosis. Radical surgery is the first choice for treatment. It has a high degree of malignancy and poor prognosis. Early diagnosis and radical surgery can improve the survival rate of patients to a certain extent.目的：探讨头颈部肉瘤样癌的病理学特征、治疗及预后。方法：回顾性分析2013年9月—2020年9月郑州大学第一附属医院收治的17例头颈部肉瘤样癌患者的临床资料，总结其病理学特性、治疗方式及随访情况，应用Kaplan-Meier法计算其总的生存率。结果：所有患者病理组织学检查可见癌成分和肉瘤成分并存，两者之间存在过渡移行区域；17例患者中，12例行手术治疗，5例因不能耐受手术或远处转移行姑息治疗；Kaplan-Meier法计算得到17例头颈部肉瘤样癌患者1、3、5年累积生存率分别为64.7%、26.5%、13.2%。结论：头颈部肉瘤样癌病理学检查是确诊的金标准，根治性手术是治疗的首选方式，其恶性程度高，预后差，早期诊断和根治性手术在一定程度上可提高患者的生存率。.

Sarcomatoid Carcinoma

Radical surgery

Distant metastasis

10.13201/j.issn.2096-7993.2022.02.010

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Comparable Survival Outcomes in Hla-Matched and Haploidentical Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Patients Aged 40-50: A Cbmtr Registry-Based Propensity Score Matching Analysis Over the Last Decade

Zhengli Xu Yuping Zhang Baodong Ye Xin Zhao Ming Zhou

Aplastic anemia

10.2139/ssrn.5039836

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Application of artificial intelligence‐based magnetic resonance imaging in diagnosis of cerebral small vessel disease

CNS Neuroscience & Therapeutics (2024)

Xiaofei Hu Li Liu Ming Xiong Jie Lu

Cerebral small vessel disease (CSVD) is an important cause of stroke, cognitive impairment, and other diseases, and its early quantitative evaluation can significantly improve patient prognosis. Magnetic resonance imaging (MRI) is an important method to evaluate the occurrence, development, and severity of CSVD. However, the diagnostic process lacks quantitative evaluation criteria and is limited by experience, which may easily lead to missed diagnoses and misdiagnoses. With the development of artificial intelligence technology based on deep learning, the extraction of high-dimensional features in imaging can assist doctors in clinical decision-making, and it has been widely used in brain function and mental disorders, and cardiovascular and cerebrovascular diseases. This paper summarizes the global research results in recent years and briefly describes the application of deep learning in evaluating CSVD signs in MRI imaging, including recent small subcortical infarcts, lacunes of presumed vascular origin, vascular white matter hyperintensity, enlarged perivascular spaces, cerebral microbleeds, brain atrophy, cortical superficial siderosis, and cortical cerebral microinfarct.

Stroke

Perivascular space

10.1111/cns.14841

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Association between nut consumption and non‐alcoholic fatty liver disease in adults

Liver International (2019)

Shunming Zhang Jingzhu Fu Qing Zhang Li Liu Meng Ge

Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population.A total of 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD.After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2-3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers.Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.

Refined grains

10.1111/liv.14164

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The Common Variant rs4444235 near BMP4 Confers Genetic Susceptibility of Colorectal Cancer: An Updated Meta-Analysis Based on a Comprehensive Statistical Strategy

PLoS ONE (2014)

Li Liu Qinji Su Lixia Li Xiaohui Lin Yu Gan

Objective We performed an updated meta-analysis, using a comprehensive strategy of a logistic regression and a model-free approach, to evaluate more precisely the role of the rs4444235 variant near the Bone morphogenetic protein-4 (BMP4) gene in susceptibility to colorectal cancer (CRC). Methods A total of 19 studies with 28770 cases and 28234 controls were included. Metagen system with logistic regression was applied to choose the most plausible genetic model for rs4444235. Generalized odds ratio (ORG) metric was used to provide a global test of relationship between rs4444235 and CRC risk. Results Metagen analysis suggested the rs4444235 fitted best to an additive model. In assessment of the additive model, heterogeneity was observed (P = 0.059, I2 = 36.1), and pooled per-allele OR was 1.08 (95% CI = 1.05–1.11). Based on the model-free approach, pooled ORG was 1.09 (95% CI = 1.05–1.14) under a random-effect model. Stratified analyses suggested heterogeneity could be in part explained by population ethnicity, study design, sources of controls, and sample size. Sensitivity analysis further supported the robust stability of the current results, by showing similar pooled estimates before and after sequential removal of each study. Conclusions This meta-analysis provides a robust estimate of the positive association between the rs4444235 and CRC risk and further emphasizes the importance of the rs4444235 in CRC risk prediction.

genetic model

10.1371/journal.pone.0100133

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Reference values for handgrip strength: data from the TCLSIH cohort study

Age and Ageing (2019)

Hongmei Wu Mingyue Liu Qing Zhang Li Liu Ge Meng

although handgrip strength (HGS) is considered an excellent predictor of morbidity and mortality, there are few reference data available, especially across life from young to old populations.to investigate the reference values and determinants for HGS in a large Chinese adult population.this cross-sectional study used data from the Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study ranging from 2013 to 2017.in total, 37,707 Chinese adults aged 18-93 years with measures of HGS were included.HGS was measured using a handheld digital dynamometer. The percentile distribution of HGS, as well as mean (standard deviation) values of HGS, was calculated according to sex and age categories. The Pearson's or Spearman's correlation coefficient and multiple linear regression were also used.the peak mean value of HGS was 45.2 ± 6.88 kg in men and 26.8 ± 4.65 kg in women. Different reference values for each sex and age category are present. The prevalence of low HGS was 7.69% in men and 6.46% in women. Multiple regression analysis showed that almost 72.5% of HGS variability can be explained by sex, age, height and weight.the HGS reached peak at 40 years old, maintained or slightly lowered between ages 40 and50 and then start an accelerated decline after 50 years old. Reference values of HGS should be stratified by sex and age group. HGS variability can be largely explained by sex, age, height and weight.

Reference values

Cross-sectional study

10.1093/ageing/afz148

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Clinical Analysis and Risk Factors of Bronchiolitis Obliterans After Mycoplasma Pneumoniae Pneumonia

Infection and Drug Resistance (2022)

Haoqi Zheng Yucong Ma Yuquan Chen Yan-Yue Xu Yan-Lin Pang

Purpose: Severe mycoplasma pneumoniae (MP) pneumonia can cause bronchiolitis obliterans (BO). In order to improve the prognosis of BO, it is necessary to grasp the clinical characteristics and risk factors of BO after severe MP pneumonia and intervene as soon as possible. Patients and Methods: This study retrospectively analyzed the clinical data of 110 patients with severe MP pneumonia, and divided them into BO group (22 cases) and non-BO group (88 cases). The clinical characteristics of BO group were analyzed, and the clinical data of two groups were compared to identify the risk factors of BO. Results: At the time of diagnosis, all BO patients had symptoms of cough and wheezing, and 10 (45.45%) had decreased exercise intolerance. Lung function showed moderate to severe obstructive ventilatory dysfunction, high-resolution computed tomography (HRCT) showed mosaic perfusion patterns. Multivariate binomial regression analysis showed that higher levels of serum lactate dehydrogenase (LDH) and hypoxemia were independent risk factors for BO after severe MP pneumonia. Conclusion: Higher levels of serum LDH and hypoxemia were independent risk factors for BO after severe MP pneumonia. For patients with risk factors, clinicians should regular follow-up for early diagnosis and intervention of BO. Keywords: children, bronchiolitis obliterans, mycoplasma pneumoniae pneumonia, post-infectious bronchiolitis obliterans, risk factors

Mycoplasma pneumonia

10.2147/idr.s372940

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Serum ferritin as an independent predictor of non-alcohol fatty liver disease in general adults: the TCLSIH cohort study

Research Square (Research Square) (2022)

Yeqing Gu Ge Meng Xiaowei Chen Jinhan Wang Qing Zhang

Abstract Background Serum ferritin is an important iron storage protein in the human body, which indicates iron storage and the body’s nutritional status, and is associated with a variety of chronic diseases. Few prospective studies have assessed the association between serum ferritin levels and non-alcoholic fatty liver disease (NAFLD). This prospective cohort study aimed to explore whether serum ferritin levels were associated with the incidence of NAFLD in a large-scale adult population. Methods A total of 15,748 participants without baseline NAFLD were enrolled in the cohort study (1-9 years follow-up periods, median: 4.5 years). Serum ferritin levels were determined by protein chip-chemiluminescence method, and NAFLD was diagnosed by abdominal ultrasonography. Multivariable Cox proportional hazards regression models were used to assess the association between baseline serum ferritin levels and the risk of NAFLD. Results During the follow-up period, 3,374 new NAFLD cases were observed, and the incidence rate of NAFLD was 83.4 per 1000 person-years. In the fully adjusted model, the hazards ratios (95% confidence interval) for incident NAFLD across serum ferritin levels quartiles were 1.06 (0.94-1.19), 1.25 (1.11-1.41), and 1.52 (1.28-1.79) ( P for trend <0.0001). Receiver operating characteristic (ROC) analysis showed that the optimal cut-off values were 55.9 mg/dl for serum ferritin levels (Area under the ROC curve (AUC)=0.61) Conclusion Increased serum ferritin level was independently associated with a higher risk of incident NAFLD in a large-scale general population. It is suggested that serum ferritin levels can be useful for the early detection of subjects at high risk of developing NAFLD.

Quartile

10.21203/rs.3.rs-1321357/v1

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