Lei Yang

Fudan University

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Co-Authors

Yuzhen Zhuo

Tianjin Nankai Hospital

Lanqiu Zhang

Tianjin Nankai Hospital

Dihua Li

Tianjin Nankai Hospital

Ximo Wang

Tianjin University

Lihua Cui

Zhejiang Chinese Medical University

Shukun Zhang

Tianjin Nankai Hospital

Botao Wang

Xiamen University

Sixu Chen

Sun Yat-sen Memorial Hospital

Xiaojian Cao

Nanjing Medical University

Caixia Li

Tianjin Nankai Hospital

Cooperative Institutions

Chinese Academy of Sciences

116

Chinese Academy of Medical Sciences & Peking Union Medical College

113

Nanjing Medical University

104

Capital Medical University

Sun Yat-sen University

Central South University

Peking University

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Tianjin Medical University

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Two New Monoterpene Glycosides from Ku-Ding-Cha. Inhibitors of Acyl-CoA: Cholesterol Acyltransferase (ACAT).

Chemical and Pharmaceutical Bulletin (1996)

Toshiyuki Fukuda Yoshio KiTADA Xinmin Chen Lei Yang Toshio Miyase

Two new monoterpene glycosides, kudingosides A and B, were isolated from Ku-Ding-Cha (Ligustrum pedunculare REHD.), together with a known monoterpene glycoside, (S)-lipedoside B-III, and three known phenylethanoid glycosides. Their structures were elucidated by spectroscopic and chemical means. Kudingosides A and B, and (S)-lipedoside B-III inhibited acyl-CoA : cholesterol acyltransferase (ACAT) with IC50 values of 2.70×10-3 M, 2.88×10-3 M, and 2.69×10-4 M, respectively.

Sterol O-acyltransferase

Monoterpene

Acyltransferases

10.1248/cpb.44.2173

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Citations (16)

A sensitivity analysis approach to principal stratification with a continuous longitudinal intermediate outcome: Applications to a cohort stepped wedge trial

arXiv (Cornell University) (2024)

Lei Yang Michael J. Daniels Fan Li

Causal inference in the presence of intermediate variables is a challenging problem in many applications. Principal stratification (PS) provides a framework to estimate principal causal effects (PCE) in such settings. However, existing PS methods primarily focus on settings with binary intermediate variables. We propose a novel approach to estimate PCE with continuous intermediate variables in the context of stepped wedge cluster randomized trials (SW-CRTs). Our method leverages the time-varying treatment assignment in SW-CRTs to calibrate sensitivity parameters and identify the PCE under realistic assumptions. We demonstrate the application of our approach using data from a cohort SW-CRT evaluating the effect of a crowdsourcing intervention on HIV testing uptake among men who have sex with men in China, with social norms as a continuous intermediate variable. The proposed methodology expands the scope of PS to accommodate continuous variables and provides a practical tool for causal inference in SW-CRTs.

Wedge (geometry)

Stratification (seeds)

10.48550/arxiv.2412.00926

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Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B

Journal of Cancer Research and Clinical Oncology (2020)

Yinan Yang Wencong Tian Lei Yang Qiong Zhang Mengmeng Zhu

10.1007/s00432-020-03384-7

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Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome Caused by Anhydrous Ammonia Burns: Two Case Reports

Journal of Burn Care & Research (2022)

Xue Heng Zhiqiang Yuan Fei Xiang Qizhi Luo Lei Yang

Abstract Acute anhydrous ammonia burns are relatively rare but lethal and often occur as a mass occupational incident worldwide. Anhydrous ammonia mainly leads to severe inhalation injury and skin/mucosa wound because of its high water solubility and strong alkalinity. Acute respiratory distress syndrome (ARDS) induced by inhalation injury is the main cause of death. Extracorporeal membrane oxygenation (ECMO), also known as extracorporeal life support, has been recommended as the salvage treatment for severe ARDS based on low-level evidence. However, the application of ECMO in ammonia burns is still limited. Here, we presented two cases of anhydrous ammonia burn patients, one 62-year-old man with 15% total body surface area (TBSA) and one 47-year-old man with 27% TBSA, accompanying severe inhalation injury. They both developed severe ARDS and started vv ECMO on 3, 6, and 15 days after injury, respectively. ECMO lasted 118, 247, and 72 h, respectively. All ECMO were successfully weaned off although only one patient survived. Meanwhile, one patient had the coagulopathy complication of ECMO, mainly bleeding, deep vein thrombosis, and hemolysis. In conclusion, this report provided evidence for use of ECMO as supportive care in ammonia burn patients with severe ARDS.

Burn center

10.1093/jbcr/irac142

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Citations (2)

Comparative efficacy and safety of Chinese herbal medicine for knee osteoarthritis: A protocol for systematic review and network meta-analysis

Boyu Wu Lei Yang Chengwei Fu Xinyu Qi Gonghui Jian

Review question / Objective: Knee osteoarthritis (OA) is a major public health concern causing chronic disability as well as a substantial burden on healthcare and the economy.However, effective treatments for knee OA were still not available.Numerous clinical studies have suggested that Chinese herbal medicine (CHM) seems to be clinically effective in treating knee OA.Thus, this study aims to evaluate the efficacy and safety of CHM in the treatment of knee OA through a systematic review and network meta-analysis.

10.37766/inplasy2021.6.0060

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Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Klebsiella pneumoniae with Ceftazidime–Avibactam-Based Regimens: a case report

International Journal of Antimicrobial Agents (2024)

Yinru Chen Wanzhen Li Xiaofen Liu Yan Chen Jing Zhang

Ceftazidime/avibactam

Ventriculitis

Avibactam

Carbapenem

Pharmacodynamics

10.1016/j.ijantimicag.2024.107356

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Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells

Leukemia (2012)

Yan Yu Lei Yang Ming Zhao Shan Zhu R Kang

Imatinib Mesylate

K562 cells

10.1038/leu.2012.65

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Citations (189)

P21.01 Selected ctDNA Panel Gene Sequencing for Neoantigen Discovery and Survival Prediction in Patients With Stage IV Non-Small Cell Lung Cancer

Journal of Thoracic Oncology (2021)

Y. Zhang Wu Dai Liangliang Xu Likun Ma Zhongcheng Liang

Exome

10.1016/j.jtho.2021.08.353

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Citations (1)

Association between dietary intake of iron and heart failure among American adults: data from NHANES 2009–2018

BMC Nutrition (2024)

Yajie Wang Jie Yang Lei Yang Liang Zheng

Patients with heart failure (HF) often experience iron deficiency. Intravenous iron supplementation has been widely used in clinical practice to facilitate the treatment of HF. However, the association between dietary iron intake and HF still needs to be elucidated. This study aimed to evaluate the impact of dietary iron intake on HF in American adults. The data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. Iron dietary intake data were obtained from two 24-h dietary recall interviews. We examined baseline data and HF prevalence in different quartile groups of dietary iron intake (Q1-Q4). Two logistic regression models were established to evaluate the impact of Q4 (highest iron consumption) on the risk of HF. The study included 20,853 American adults (age ≥ 20 years). The participants with the highest iron intake (Q4) had the lowest prevalence of HF (Q1: 3.25%, Q2: 2.18%, Q3: 1.92%, Q4: 1.72%; P < 0.001). After adjusting for possible confounding factors, the highest iron intake (Q4) was significantly associated with a reduced risk of HF compared with that of Q1 (odds ratio 0.58, 95% confidence interval 0.41-0.82; P = 0.003). This association remained stable in subgroups of women, current smokers, and Hispanics other than Mexican Americans. This study revealed that the dietary intake of iron was negatively associated with HF in adults without exceeding the tolerable maximum daily intake of 45 mg/day.

Clinical nutrition

Lipidology

Association (psychology)

10.1186/s40795-024-00957-4

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流れ場の結合と種々の流体力学的条件下での生態学的浮遊ベッドの根系領域における浄化効率【Powered by NICT】

Lei Rao Peifang Wang Lei Yang Chao Wang

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