Abstract High-entropy alloys have received considerable attention in the field of catalysis due to their exceptional properties. However, few studies hitherto focus on the origin of their outstanding performance and the accurate identification of active centers. Herein, we report a conceptual and experimental approach to overcome the limitations of single-element catalysts by designing a FeCoNiXRu (X: Cu, Cr, and Mn) High-entropy alloys system with various active sites that have different adsorption capacities for multiple intermediates. The electronegativity differences between mixed elements in HEA induce significant charge redistribution and create highly active Co and Ru sites with optimized energy barriers for simultaneously stabilizing OH * and H * intermediates, which greatly enhances the efficiency of water dissociation in alkaline conditions. This work provides an in-depth understanding of the interactions between specific active sites and intermediates, which opens up a fascinating direction for breaking scaling relation issues for multistep reactions.
The exfoliation of bulk two-dimensional metal–organic framework (MOF) into few-layered nanosheets has attracted much attention recently. In this work, an environmental-friendly route has been developed for layered-MOF (MAMS-1) delamination using deep eutectic solvent (DES), which is more sustainable and efficient alternative than conventional organic solvents for MOF nanosheet preparation. Under sonication condition, DES as solvents, the highest exfoliation rate of MAMS-1 is up to 70% with two host layers via poly(vinylpyrrolidone) (PVP) surfactant-assisted method. The presence of tert-butyl exteriors and the atomically thickness endow the MOF nanosheets stable suspension for at least one month. Due to the 2D structure and excellent stability, MAMS-1 nanosheet (MAMS-1-NS) was chosen as a good candidate to encapsulate Eu3+ cations. The obtained Eu3+@MAMS-1-NS acts as a multi-responsive luminescent sensor through fluorescence quenching, and can specifically recognize Fe3+ (LOD = 0.40 μM, KSV = 1.05 × 105 M−l), Hg2+ (LOD = 0.038 μM, KSV = 5.78 × 106 M−l), Cr2O72− (LOD = 0.33 μM, KSV = 1.55 × 105 M−l) and MnO4− (LOD = 0.088 μM, KSV = 4.49 × 105 M−l). Compared with bulk Eu3+@MAMS-1, the sensitivity of Eu3+@MAMS-1-NS is greatly improved owing to its ultrathin nanosheet morphology and highly accessible active sites on the surface.
Surface state-controlled C-dots/C-dots based dual-emission fluorescent nanothermometer is achieved which can use for the visual measurement of intracellular temperature variations.
Ni-based superalloys are used as turbine blade material in which creep-fatigue is an important damage mechanism. Simulation and experiment methods are used to investigate and predicte the failure mechanism of the first stage high pressure turbine blades of an aeroengine after 600 hours service. The high pressure turbine blades were made of Ni-base superalloy DZ4, fabricated by DS investment casting. The largest stress point was obtained by finite element analysis. During the fatigue test, the high temperature and low cycle fatigue/creep load simulating the real working condition were applied on the blades until they fractured. And then several examinations were carried out to identify the fracture’s main cause, such as visual examination, SEM fractography and microstructural characterization. In conclusion, the fracture of the high pressure turbine blades was mainly caused by the interaction of the fatigue and creep. Besides, the oxidation accelerated the blades fracture.
The protein corona effect refers to the phenomenon wherein nanomaterials in the bloodstream are coated by serum proteins, yet how protein coronated nanomaterials interact with blood vessels and its toxicity implications remain poorly understood. In this study, we investigated protein corona-related vessel toxicity by using an all-humanized assay integrating blood vessel organoids and patient-derived serum. Initially, we screened various nanomaterials to discern how parameters including size, morphology, hydrophobicity, surface charge, and chirality-dependent protein corona difference influence their uptake by vessel organoids. For nanomaterials showing substantial differences in vessel uptake, their protein corona was analyzed by using label-free mass spectra. Our findings revealed the involvement of cancer staging-related cytoskeleton components in mediating preferential uptake by cells, including endothelial and mural cells. Additionally, a transcriptome study was conducted to elucidate the influence of nanomaterials. We confirmed that protein coronated nanomaterials provoke remodeling at both transcriptional and translational levels, impacting pathways such as PI3K-Akt/Hippo/Wnt, and membraneless organelle integrity, respectively. Our study further demonstrated that the remodeling potential of patient-derived protein coronated nanomaterials can be harnessed to synergize with antiangiogenesis therapeutics to improve the outcomes. We anticipate that this study will provide guidance for the safe use of nanomedicine in the future.
Time reversal technique as an excellent channel equalization technology which can restrain multipath effectively to implementation time focusing and can improve the distribution of energy in space to implementation spatial focusing.This paper aim to improve the shortcomings with p oo r ac c u rac y of p os it io n i ng, a l arg e amo u nt of calculation,sensitive to the environment for the existing location method indoor.whatmake full use of strongly time resolution and spatiotemporal focusing characteristics of TR in UWB.From the perspective of collection multipath energy,which brings together time reversal theory,UWB technology TOA to research the effect factor of obstacles in NLOS environment.This paper introduce ranging process of windowed time reversal in indoor environment.With a large number of ranging experiment are carried out,analysed the sources of measurement error in NLOS environment and compared its effects.Simulation results show that the influence of obstacles on ranging.From large to small in turn as the length,width and position which lay the foundation for the next positon.
Abstract The protein corona effect has long been treated as the evil source behind delivery efficacy issues. In this study, this concept is challenged by showcasing that the protein corona can serve as a versatile functionalization approach to improve the delivery efficacy or mitigate nanocytotoxicity. To this end, the depleted serum is introduced to create nanomaterials carrying functionally distinct protein corona, referred to as PCylated nanomaterials. It is confirmed that the passivation with depleted serum helps reduce the toxicity and pro‐inflammatory response. Furthermore, the same method can be leveraged to enhance the capacity of nanomaterials to undergo endocytosis as well as their potential as an agonist for the NF‐κB pathways. The comparable stability of protein corona created by late and early‐stage serum reveals that the chanceless interaction with nanomaterials, rather than an inadequate binding strength, may be behind the failure of enriching certain components. The PCylation strategy is extended to cancer patient‐derived fluid, creating a set of T1 and T3‐stage cancer‐specific nanotherapeutics to retard the metastasis of cancer cells, while leaving normal endothelial negligibly affected. It is hoped the novel PCylation approach validated here can shed light on the future development of precision nanomedicine with improved delivery efficacy.
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