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10.2139/ssrn.4764467

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Protein Tyrosine Phosphatase Activity and Functional Collaboration between IGF-I Receptor and GH Signal Transduction in Primary Osteoblasts

Yujun Gan Yue Zhang Jin Jiang Stuart J. Frank

10.1210/endo-meetings.2011.part2.p35.p2-353

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Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation

Frontiers in Microbiology (2020)

Lantian Zhou Yue Zhang Yongze Ge Xuan Zhu Jianyi Pan

A biofilm is an assemblage of microbial cells attached to a surface and encapsulated in an extracellular polymeric substance (EPS) matrix. The formation of a biofilm is one of the important mechanisms of bacterial resistance, which not only leads to hard-to-control bacterial infections in humans and animals but also enables bacteria to be a major problem in various fields, such as food processing, wastewater treatment and metalworking. Quorum sensing (QS) is a bacterial cell-to-cell communication process that depends on the bacterial population density and is mediated by small diffusible signaling molecules called autoinducers (AIs). Bacteria use QS to regulate diverse arrays of functions, including virulence and biofilm formation. Therefore, the interference with QS by using QS inhibiting agents, including QS inhibitors (QSIs) and quorum quenching (QQ) enzymes, to reduce or even completely repress the biofilm formation of pathogenic bacteria appears to be a promising approach to control bacterial infections. In this review, we summarize the mechanisms of QS-regulating biofilm formation and QS-inhibiting agents that control bacterial biofilm formation, strategies for the discovery of new QS inhibiting agents, and the current applications of QS-inhibiting agents in several fields to provide insight into the development of effective drugs to control pathogenic bacteria.

Autoinducer

Quorum Quenching

Extracellular polymeric substance

Pathogenic bacteria

10.3389/fmicb.2020.589640

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2019 26th IEEE International Conference on Electronics, Circuits and Systems (ICECS)

2021 28th IEEE International Conference on Electronics, Circuits, and Systems (ICECS) (2019)

Shuo Li Lina Shi Xun Zhang Andrei Vladimirescu Zhan Wang

10.1109/icecs46596.2019

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Evaluation of the resistance and resilience of terrestrial ecosystems to drought in southwest China

Journal of Hydrology (2024)

Yuzhen Li Qingwei Zhuang Hongfei Zhao Wenqiang Zhang Peng Cai

Resilience

Terrestrial ecosystem

Drought Resistance

10.1016/j.jhydrol.2024.132318

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Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

BMC Cancer (2022)

Xiaoya Luo Yue Zhang Ying Meng Ming Ji Yongjun Wang

Abstract Background Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues. Many studies have shown that KLF4 has various mechanisms in different tumours; however, the prognostic role of KLF4 remains unclear. Methods and results We searched the relevant literature that evaluated the prognostic value of KLF4 in different cancers, and the original survival data were obtained from the text, tables or Kaplan–Meier curves for both comparative groups. Thirty studies were included in this meta-analysis, and a total of 10 malignant tumours were involved. The expression of KLF4 was not associated with the prognosis for overall survival (hazard ratio(HR)0.86, 95% confidence interval (CI): 0.65–1.13, P = 0.28), disease-free survival/recurrence-free survival/metastasis-free survival (HR 0.87, 95% CI: 0.52–1.44, P = 0.58) or disease-specific survival (HR 1.13, 95% CI: 0.44–2.87, P = 0.8). Conclusion This study showed that the expression of KLF4 was not related to the prognosis of the tumours that were included in the study.

Surgical oncology

10.1186/s12885-022-09198-9

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Host genetic regulation of human gut microbial structural variation

Nature (2024)

Daria V. Zhernakova Daoming Wang Lei Liu Sergio Andreu‐Sánchez Yue Zhang

Although the impact of host genetics on gut microbial diversity and the abundance of specific taxa is well established

Faecalibacterium prausnitzii

Human genetic variation

Human genetics

Genome-wide Association Study

10.1038/s41586-023-06893-w

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Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma

bioRxiv (Cold Spring Harbor Laboratory) (2022)

Fang Chen Shenghui Li Ruochun Guo Fanghua Song Yue Zhang

Abstract Introduction Gut microbiome plays an important role in maintaining human health. Although mounting evidence has revealed the critical function of the gut bacteriome in the progression of CRC, the contribution of gut viral community to CRC is rarely studied. Objectives The present study aimed to reveal the gut virome signatures of colorectal adenoma patients and CRC patients and decipher the potential viral markers to build clinical predictive models for diagnosis. Methods 1,282 available fecal metagenomes data from 9 published CRC studies were collected. A new virus database was constructed based on a reference-independent virome approach for further analysis. Viral markers were filtered by statistical methods and used to build machine learning models such as Random Forest and Least Absolute Shrinkage and Selection Operator (LASSO) to distinguish patients from controls. New fecal samples were collected to validate the generalization of predictive model. Results The gut viral composition of CRC patients was drastically altered compared with healthy, as evidenced by changes in several Siphoviridae viruses and a reduction of Microviridae, whereas the virome variation in adenoma patients was relatively low. The viral markers contained the phages of Porphyromonas , Fusobacterium , Hungatella , and Ruminococcaceae . In 9 cohorts and independent validation cohorts, a random forest (RF) classifier and LASSO model got the optimal AUC 0.830 and 0.906, respectively. While the gut virome analysis of adenoma patients identified 88 differential viruses and achieved an optimal AUC of 0.772 for discriminating patients from controls. Conclusion Our findings demonstrate the distinctly different composition of gut virome between healthy controls and CRC patients, and highlight the potential of viral markers for clinical diagnosis.

Human virome

Faecalibacterium prausnitzii

Siphoviridae

Colorectal adenoma

10.1101/2022.07.17.500372

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