Spindle cell carcinoma (SpCC) is a rare tumor type with poor prognosis, and standard treatment modalities are not available yet. However, large-scale studies on this topic are sparse. In this study, data from the surveillance, epidemiology, and end results (SEER) database were used to determine cancer-specific survival (CSS) rates of SpCC and to investigate the impact of different therapeutic strategies including surgery with or without chemotherapy, radiotherapy, or chemoradiotherapy on patient outcome.A total of 665 cases of SpCC, diagnosed from 1996 to 2015, were extracted from the SEER database. Kaplan-Meier survival curves and log-rank tests were used to assess CSS rates and differences on survival curves. Multiple COX-proportional hazards models were used to analyze the association between various treatments and prognosis of SpCC patients classified by organs or systems.Different treatments for SpCC in different organ or system were associated with prognosis of SpCC patients. Surgery alone exhibits survival benefit, whereas adjuvant therapy fails to show survival benefit for patients with SpCC.The prognosis of SpCC patients varied significantly with different clinical treatments. Adjuvant radiotherapy or chemotherapy did not show survival benefit, even increasing the risk of mortality for SpCC patients.
Ag?Ni?SiO2 nano-composite particles were produced using a pulsed laser control synthesis method comprising a gas phase evaporation and liquid phase collection method. The targets were mixtures composed of micron sized powders consisting of 4%, 7% and 10% Ni powder mixed with 20% SiO2 powder and Ag powder. The morphology, structure and synthesis mechanism of the nano-composite particles were studied by means of TEM, XRD, and IR and UV spectroscopy. The results indicate that the Ag?Ni?SiO2 nano-composite particles prepared with this method are spherical with good dispersion. The diameters of the primary particles were found to range from 5 nm to 35 nm and the Ag?Ni?SiO2 nano-composite particles were found to have a mixed composite structure. The saturation magnetization of the Ag?Ni?SiO2 nano-composite particles increased gradually with the increase of Ni content. The ethylene glycol in the liquid phase is adsorbed onto the surface of the nano-composite particles and this plays a role in the in situ dispersing of the Ag?Ni?SiO2 nano-composite particles.
One of the key challenges faced by autistic children is understanding social affordances in complex environments, which further impacts their ability to respond appropriately to social signals. In traffic scenarios, this impairment can even lead to safety concerns. In this paper, we introduce an LLM-simulated immersive projection environment designed to improve this ability in autistic children while ensuring their safety. We first propose 17 design considerations across four major categories, derived from a comprehensive review of previous research. Next, we developed a system called AIroad, which leverages LLMs to simulate drivers with varying social intents, expressed through explicit multimodal social signals. AIroad helps autistic children bridge the gap in recognizing the intentions behind behaviors and learning appropriate responses through various stimuli. A user study involving 14 participants demonstrated that this technology effectively engages autistic children and leads to significant improvements in their comprehension of social affordances in traffic scenarios. Additionally, parents reported high perceived usability of the system. These findings highlight the potential of combining LLM technology with immersive environments for the functional rehabilitation of autistic children in the future.
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