Aortic valve regurgitation complicating blunt chest trauma is rare. We describe a case of a 73-year-old male with history of car accident complicated by sternal fracture in 2002. In 2019 he was a candidate for liver metastasis resection complicating adenocarcinoma of the rectum but, for the finding of a holosystolic murmur, he underwent trans-esophageal echocardiography. This showed severe aortic regurgitation due to the fracture of the right coronary cusp. Heart Team decided upon the replacement of the aortic valve with biological prosthesis. Probably, the blunt chest trauma provoked an initial right cusp lesion and the regurgitation worsened over time.

Blunt trauma

10.22541/au.170665584.43192050/v1

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Impact of Moderate Ischemic Mitral Regurgitation After Isolated Coronary Artery Bypass Grafting

The Annals of Thoracic Surgery (2010)

Khalil Fattouch Roberta Sampognaro Giuseppe Speziale Massimo Salardino Giuseppina Novo

10.1016/j.athoracsur.2010.03.103

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Sacubitril/valsartan reduces indications for arrhythmic primary prevention in heart failure with reduced ejection fraction: insights from DISCOVER-ARNI, a multicenter Italian register

European Heart Journal Open (2021)

Maria Concetta Pastore Giulia Elena Mandoli Alberto Giannoni Giovanni Benfari Frank Lloyd Dini

This sub-study deriving from a multicentre Italian register [Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril-Valsartan: A Multicenter Echocardiographic Registry (DISCOVER)-ARNI] investigated whether sacubitril/valsartan in addition to optimal medical therapy (OMT) could reduce the rate of implantable cardioverter-defibrillator (ICD) indications for primary prevention in heart failure with reduced ejection fraction (HFrEF) according to European guidelines indications, and its potential predictors.

Sacubitril, Valsartan

Sacubitril

10.1093/ehjopen/oeab046

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A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research

Nutrients (2024)

Anna Vittoria Mattioli Francesca Coppi Paolo Severino Cláudia Penna Pasquale Pagliaro

Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.

Cardiovascular Health

10.3390/nu17010115

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EFFECTS OF FOUR DIFFERENT ANTIHYPERTENSIVE TREATMENTS ON CARDIAC ARRHYTHMIAS AND TRANSIENT EPISODES OF MYOCARDIAL ISCHEMIA IN HYPERTENSIVES WITH LEFT VENTRICULAR HYPERTROPHY

Journal of Hypertension (2000)

Maurizio Giuseppe Abrignani Giuseppina Novo Emilio Nardi R Caruso R Tantillo

Abrignani, M. G.1; Novo, G.2; Nardi, E.2; Caruso, R.3; Tantillo, R.; Braschi, A.2; Novo, S.2 Author Information

10.1097/00004872-200006001-00248

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Impact of Metabolic Syndrome on Coronary Microvascular Dysfunction: A Single Center Experience

Cardiology and Cardiovascular Medicine (2023)

Vincenzo Sucato Cristina Madaudo Luca Di Fazio Girolamo Manno G Vadalà

Coronary microvascular dysfunction (CMD) represents a widespread condition and a prevalent cause of ischemic heart disease. Total TIMI frame count (TTFC) can be a good indicator of CMD in different populations. The aim of our study was to evaluate the incidence of CMD in different populations such as METS patients compared with diabetic and hypertensive patients. The study was carried out on patients with chest pain and/or positive stress test and angiographically undamaged coronary arteries. Our CMD population was divided into three subgroups; patients with arterial hypertension, patients with type II diabetes mellitus and patients with metabolic syndrome. TIMI Frame Count (TFC) and Myocardial Blush Grade (MBG) are indices used to evaluate the degree of microcirculatory dysfunction, in particular the TIMI frame count and the Myocardial Blush degree.

TIMI

Coronary arteries

10.26502/fccm.92920320

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Citations (2)