Hiromichi Ohnishi

Kagawa Prefectural Central Hospital

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CLINICAL STUDY ON THE CARBOHYDRATE METABOLISM AND PANCREATIC ENDOCRINE FUNCTION AFTER ESOPHAGECTOMY

The Japanese Journal of Gastroenterological Surgery (1982)

Takaaki Sudo Sei Shiraha Kenji Ishiyama Masahiko Takemoto T. Asakawa

食道癌患者は, 高齢者が多く, 大なり小なり糖代謝障害を来しているが, 食道癌の手術は, さらに手術侵襲を加えることとなり, また食道切除に伴う幹迷切の結果, 糖代謝に関与する膵内分泌機能, とくに, インスリン, グルカゴン分泌に影響をおよぼすものと思われる.術前および術後1ヵ月にトレーランG150mlを経口負荷し, 血糖値, インスリン値, グルカゴン値を測定するとともに, コントロール群と術後1ヵ月に経静脈的にブドウ糖0.5g/kgを注入し, 血糖値, インスリン値, グルカゴン値を測定し, インスリン, グルカゴンの糖代謝におよぼす影響について検討し, 次の結果を得た.経口負荷試験では, 食道癌患者は, コントロール群にくらべて, インスリン分泌機能は低下していたが, 術後は, インスリン分泌機能は, 早期には亢進し, 後期には低下した.グルカゴン分泌は著明に亢進しており, 食道癌手術後の糖代謝障害に高グルカゴン血症が関与していることが示唆された.経静脈負荷試験では, 術後はインスリン分泌反応とグルカゴン分泌抑制反応が低下しており, 幹迷切の影響を強く受ける事が判明した.

Carbohydrate Metabolism

Esophagectomy

10.5833/jjgs.15.1881

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Citations (1)

Hypoxia Increases Transforming Growth Factor-β1 Concomitantly with Types I and III Collagen without Further Enhancement by Reoxygenation in Cultured Rat Cardiac Fibroblasts

Connective tissue (1998)

Hiroshi Nunoyama Shozo Kusachi Yoshifumi Ninomiya Toshitaka Oohashi Jun Kondo

Hypoxia

Source

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Citations (3)

Reperfusion accelerates the distribution of type I and III collagen messenger RNA expression after acute myocardial infarction

Coronary Artery Disease (1999)

Hiroki Moritani Shozo Kusachi Kenji Takeda Masayuki Doi Hiromichi Ohnishi

The effects of reperfusion on the time-dependent appearance and distribution of type I and III collagen messenger RNA (mRNA) expression had not hitherto been examined.To compare the sequential changes in the extent of distribution of type I and III collagen mRNA expression in reperfused infarct hearts of rats with those in unreperfused infarct hearts.Using an experimental rat model of infarction, we examined type I and III collagen mRNA expression with specific rat pro alpha 1 (I) and human pro alpha 1 (III) collagen riboprobes by in-situ hybridization. Reperfusion was established after a 2 h coronary ligation that produced complete necrosis of the myocytes.Positive signals both for alpha 1 (I) and for alpha 1 (III) collagen mRNA appeared in the infarct peripheral zone 12 h after coronary ligation both of the reperfused and of unreperfused hearts. The spread of signal into the infarct central zone occurred 1-2 days earlier for the reperfused hearts than it did for the unreperfused hearts. The difference between the distributions of signals for the reperfused and unreperfused hearts became obscure on day 14. No notable difference between the extents of signal distribution for alpha 1 (I) and alpha 1 (III) collagen mRNA was obtained. We observed intense signals from spindle-shaped mesenchymal cells (myofibroblasts and fibroblasts) located between surviving myocytes in the marginal zone of the infarct. No myocyte exhibited signals both for alpha 1 (I) and for alpha 1 (III) collagen mRNA.In the present study, using in-situ hybridization, we demonstrated that reperfusion accelerates the distribution of expression both of alpha 1 (I) and of alpha 1 (III) collagen mRNA in the infarct zone after acute myocardial infarction in rats.

10.1097/00019501-199903000-00005

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Citations (4)

Abstract 3167: Serum Activin A Level Is Associated With Infarct Size In Patients With Acute Myocardial Infarction Who Undergo Successful Primary Percutaneous Coronary Intervention

Circulation (2007)

Toru Miyoshi Satoshi Hirohata Tadahisa Uesugi Minoru Hirota Hiromichi Ohnishi

PURPOSE: Activin A, a member of the transforming growth factor-beta cytokine family, has been suggested to play a role in inflammation and have pleiotropic functions. We examined the alteration of serum activin A level in patients with ST-segment elevation myocardial infarction (STEMI) who received successful primary percutaneous coronary intervention (PCI) within 12 hours, and investigated whether serum activin A was associated with infarct size. METHODS: We examined 26 patients with STEMI, 20 consecutive stable angina pectoris (AP) patients and 20 normal subjects. In STEMI patients, blood samples were collected before PCI (day0) and days 1, 2, 7 and 14. Serum activin A level was measured by enzyme-linked immunoassay. Change of activin A between day 2 and day0 (delta 2d) was also examined. The serum levels of activin A were compared with infarct size, as indicated with peak CK. RESULTS: Patients with STEMI demonstrated significantly higher serum activin A level (before PCI) than control subjects and patients with AP (316±112, 369±153 and 569±272 pg/ml, p<0.001 and p=0.007, respectively). The activin A level was significantly elevated and peaked on day 0 and reduced on days 2, and then gradually increased until days 14. Log-transformed peak CK was significantly correlated with serum activin A level on day0 (r=0.55, p=0.004) and delta 2d (r=0.58, p=0.023). In stepwise analysis, serum activin A level (beta=0.37, p=0.022) as well as age, culprit lesion (LAD) and smoking was an independent predictor of peak CK. CONCLUSIONS: The findings suggest that serum activin A level was elevated in STEMI and it may be associated with infarct size in STEMI patients.

10.1161/circ.116.suppl_16.ii_711-a

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Citations (0)

Double-sector Lorenz plot scattering in an R-R interval analysis of patients with chronic atrial fibrillation: Incidence and characteristics of vertices of the double-sector scattering

Journal of Electrocardiology (1998)

Takefumi Oka Takaaki Nakatsu Shozo Kusachi Youkou Tominaga Shinji Toyonaga

Atrioventricular node

Effective refractory period

10.1016/s0022-0736(98)90138-8

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Citations (15)

Inverse Correlation Between Seasonal Changes in Home Blood Pressure and Atmospheric Temperature in Treated-Hypertensive Patients

Clinical and Experimental Hypertension (2010)

Akihiro Iwabu K. Konishi Hiroe Tokutake Shinichi Yamane Hiromichi Ohnishi

We examined the relationships between home blood pressure (BP) and atmospheric temperature in 20 treated-hypertensive patients. A significant correlation between morning and evening BP and atmospheric temperature was found. For morning systolic blood pressure (SBP), the maximal seasonal difference was 13.2 mmHg with 25.5°C temperature difference. Morning SBP increased by approximately 0.41 mmHg with a 1°C decrease in atmospheric temperature. A similar but weaker correlation with temperature was observed for morning diastolic, evening systolic and diastolic blood pressure (DBP). The present study provides important information in respect to BP changes with atmospheric temperature that should be taken into account in the analysis and treatment of hypertension.

10.3109/10641963.2010.491886

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Citations (19)

Expression of Perlecan Proteoglycan in the Infarct Zone of Mouse Myocardial Infarction

Journal of Molecular and Cellular Cardiology (2000)

Makoto Nakahama Takashi Murakami Shozo Kusachi Ichiro Naito Kenji Takeda

Perlecan

Immunostaining

Granulation tissue

10.1006/jmcc.2000.1146

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Citations (20)

Low Incidence of Minor Myocardial Damage Associated with Coronary Stenting Detected by Serum Troponin T Comparable to That with Balloon Coronary Angioplasty.

Japanese Heart Journal (1998)

Nobuhiko Ohnishi Katsurô Iwasaki Shozo Kusachi Ryoichi Hirami Shigeru Matano

The use of the serum troponin T (TnT) level as a means of assessing minor myocardial injury, which affects the long-term prognosis, has not been fully clarified in patients with coronary artery disease in whom a coronary stent has been implanted. We measured the TnT level to determine the incidence of myocardial damage associated with stent implantation. A total of 29 patients who underwent successful stent implantation (stenting group) were studied and compared with 45 patients who underwent successful coronary balloon angioplasty during the same period (balloon angioplasty group). The serum TnT level was measured by enzyme immunoassay 36 hours after the stenting or balloon angioplasty. The activities of serum creatine kinase (CK) and its isoenzyme MB (CK-MB) were measured by a modified Rosalski method and an immunoinhibition method, respectively, before, immediately after, and 6, 12, and 24 hours after the procedure. Elevation of the TnT level was found in 3.4% (1/29; 0.35ng/ml) of the patients in the stenting group and in 8.9% (4/45; 0.75±0.21ng/ml) of those in the balloon angioplasty group. Elevation of the CK and CK-MB activities was found in 3.4% (1/29; 163IU/l) and 0%, respectively in the stenting group, and 15.5% (7/45; 375±143IU/l) and 4.4%(2/45; 24 and 49 IU/l), respectively, in the balloon angioplasty group. TnT elevation was not invariably accompanied by CK or CK-MB elevation, or by angiographically visible side branch occlusion. For TnT, CK-MB activity and CK activity, there was no significant difference between in the incidence of elevation in the balloon angioplasty group and that in the stenting group. In summary, the incidence of myocardial damage associated with stent implantation seems to be low and comparable to that associated with balloon angioplasty. Despite the low incidence, measurement of the serum TnT level in addition to CK-MB measurement is essential in assessing minor myocardial damage.

Coronary stenting

10.1536/ihj.39.139

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Citations (11)

Reperfusion accelerates the distribution of type I and III collagen messenger RNA expression after acute myocardial infarction

Coronary Artery Disease (1999)

Hiroki Moritani Shozo Kusachi Kenji Takeda Masayuki Doi Hiromichi Ohnishi

Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.

10.1097/00019501-199910001-00005

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Citations (1)

Increased Expression of Connective Tissue Growth Factor in the Infarct Zone of Experimentally Induced Myocardial Infarction in Rats

Journal of Molecular and Cellular Cardiology (1998)

Hiromichi Ohnishi Takefumi Oka Shozo Kusachi Tohru Nakanishi Kenji Takeda

Myofibroblast

Granulation tissue

10.1006/jmcc.1998.0799

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Citations (121)