Wenze Deng

Civil Aviation Flight University of China

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Fuzhou Hua

Second Affiliated Hospital of Nanchang University

Wen Yu

Nanchang University

Lanqian Zhou

Nanchang University

Hailin Liu

Luoyang Central Hospital Affiliated to Zhengzhou University

Yao Dong

Second Affiliated Hospital of Nanchang University

Qingcui Zheng

Second Affiliated Hospital of Nanchang University

Peng Cheng

Civil Aviation Flight University of China

Yue Lin

Centre for Inflammation Research

Haotian Ren

Civil Aviation Flight University of China

You Wang

Civil Aviation Flight University of China

Cooperative Institutions

Nanchang University

Civil Aviation Flight University of China

Second Affiliated Hospital of Nanchang University

First Affiliated Hospital of Jiangxi Medical College

Education Department of Jiangxi Province

Sichuan University

University of Electronic Science and Technology of China

Jiangxi Provincial People's Hospital

Chengdu University

Inner Mongolia Agricultural University

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Gut Metabolites Acting on the Gut-Brain Axis: Regulating the Functional State of Microglia

Aging and Disease (2023)

Wenze Deng Pengcheng Yi Yanhong Xiong Jun Ying Yue Lin

The gut-brain axis is a communication channel that mediates a complex interplay of intestinal flora with the neural, endocrine, and immune systems, linking gut and brain functions. Gut metabolites, a group of small molecules produced or consumed by biochemical processes in the gut, are involved in central nervous system regulation via the highly interconnected gut-brain axis affecting microglia indirectly by influencing the structure of the gut-brain axis or directly affecting microglia function and activity. Accordingly, pathological changes in the central nervous system are connected with changes in intestinal metabolite levels as well as altered microglia function and activity, which may contribute to the pathological process of each neuroinflammatory condition. Here, we discuss the mechanisms by which gut metabolites, for instance, the bile acids, short-chain fatty acids, and tryptophan metabolites, regulate the structure of each component of the gut-brain axis, and explore the important roles of gut metabolites in the central nervous system from the perspective of microglia. At the same time, we highlight the roles of gut metabolites affecting microglia in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders. Understanding the relationship between microglia, gut microbiota, neuroinflammation, and neurodevelopmental disorders will help us identify new strategies for treating neuropsychiatric disorders.

Gut–brain axis

10.14336/ad.2023.0727

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Citations (9)

Author response for "Mechanical properties of the brain: Focus on the essential role of Piezo1‐mediated mechanotransduction in the CNS"

Qingcui Zheng Hailin Liu Wen Yu Yao Dong Lanqian Zhou

Mechanotransduction

Piezo1

10.1002/brb3.3136/v2/response1

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Mechanical properties of the brain: Focus on the essential role of Piezo1‐mediated mechanotransduction in the CNS

Brain and Behavior (2023)

Qingcui Zheng Hailin Liu Wen Yu Yao Dong Lanqian Zhou

Abstract Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes. Piezo type mechanosensitive ion channel component 1 (Piezo1), a protein found in metazoans, is highly expressed in the brain and involved in sensing changes of the mechanical microenvironment. Numerous studies have shown that Piezo1‐mediated mechanotransduction is closely related to glial cell activation and neuronal function. However, the precise role of Piezo1 in the brain requires further elucidation. Objective This review first discusses the roles of Piezo1‐mediated mechanotransduction in regulating the functions of a variety of brain cells, and then briefly assesses the impact of Piezo1‐mediated mechanotransduction on the progression of brain dysfunctional disorders. Conclusions Mechanical signaling contributes significantly to brain function. Piezo1‐mediated mechanotransduction regulates processes such as neuronal differentiation, cell migration, axon guidance, neural regeneration, and oligodendrocyte axon myelination. Additionally, Piezo1‐mediated mechanotransduction plays significant roles in normal aging and brain injury, as well as the development of various brain diseases, including demyelinating diseases, Alzheimer's disease, and brain tumors. Investigating the pathophysiological mechanisms through which Piezo1‐mediated mechanotransduction affects brain function will give us a novel entry point for the diagnosis and treatment of numerous brain diseases.

Mechanotransduction

Piezo1

Neurite

10.1002/brb3.3136

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Citations (13)

MnBi2Te4 Thin-Film Photodetector with a Millisecond Response Speed and Long-Term Air Stability

Coatings (2024)

Ming Yang Haotian Ren Wenze Deng Haoliang Chang Qiqin Li

Topological materials with well-defined surfaces and edges have become a prominent research topic. As topological insulators, MnBi2Te4 thin films, with their unique surfaces, exhibit exceptional electron transport properties and good applicability in low-noise, high-sensitivity photoelectric detection. This paper reports a straightforward, efficient, and cost-effective thermal evaporation method for preparing quantum MnBi2Te4 thin films, along with an investigation into their photoelectric detection performance. These films can be used to fabricate array devices, with the resulting photodetectors achieving a response current of 97 mA W−1 at room temperature and a response speed of <1 ms. Moreover, they demonstrate stability in the air for >30 d, with the photoelectric performance degrading by <15%. Our research introduces a new application for topological materials in photoelectric detection and establishes a strong foundation for the design and development of high-performance photodetectors in the future.

Millisecond

Response time

10.3390/coatings14091134

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Research on Forest Fire Target Detection and Tracking Based on Drones

Gui Fu Guangyan Xiong You Wang Peng Cheng Wenze Deng

Drone

Tracking (education)

10.1145/3672758.3672859

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