Maria Teresa Berlingieri

Thyroid carcinoma is one of the most common malignancies of the endocrine system, and, despite the high frequency of oncogene activation in thyroid neoplastic lesions, the tumor suppressor genes involved in thyroid carcinogenesis remain unidentified. Our previous data implicated a link between the CL2/CCDC80 gene and thyroid cancer. The objective of the study was to examine the expression of the CL2/CCDC80 gene in human thyroid carcinomas in the attempt to determine whether it plays a role in thyroid carcinogenesis. We evaluated the expression of CL2/CCDC80 in a large number of thyroid neoplastic tissue samples differing in degree of malignancy. We also investigated the effects of its restoration in 2 human thyroid carcinoma cell lines characterized by very low levels of CL2/CCDC80 expression. CL2/CCDC80 expression was much lower in almost all the thyroid carcinomas analyzed than in normal thyroid tissues and was lowest in follicular variants of papillary carcinomas. Loss of heterozygosity partially accounted for CL2/CCDC80 down-regulation in thyroid carcinoma samples. Restoration of CL2/CCDC80 expression in the 2 human thyroid anaplastic carcinoma cell lines resulted in a higher susceptibility to apoptosis and suppression of the malignant phenotype. CL2/CCDC80 expression positively regulated the expression of E-cadherin, thereby halting cancer progression. These results indicate that CL2/CCDC80 is a putative tumor suppressor gene in thyroid carcinogenesis.

10.1210/jc.2012-2926

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Citations (38)

UbcH10 GENE EXPRESSION AS A MARKER FOR DIAGNOSIS AND PROGNOSIS OF OVARIAN CANCER: 00020

International Journal of Gynecological Cancer (2007)

Maurizio Guida D. Mandato Maria Teresa Berlingieri Pierlorenzo Pallante Stefania Sparice

10.1136/ijgc-00009577-200707000-00050

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Citations (0)

Effect of viral oncogenes transformation on TSH- and norepinephrine-evoked [Ca++]i increase in rat thyroid cells

Pharmacological Research (1992)

Olimpia Meucci Antonella Scorziello Maria Teresa Berlingieri M. Grimaldi Antonio Avallone

10.1016/1043-6618(92)90787-c

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Supplementary Figure 1 from Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer

Pierlorenzo Pallante Antonio Federico Maria Teresa Berlingieri Mimma Bianco Angelo Ferraro

Supplementary Figure 1 from Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer

10.1158/0008-5472.22376592.v1

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Thyroid Neoplastic Transformation In Vitro and In Vivo

Springer eBooks (1984)

Alfredo Fusco Pier Paolo Di Fiore Maria Teresa Berlingieri Giulia Colletta Anna Maria Cirafici

Tumor Virus

10.1007/978-1-4684-4856-6_27

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Citations (1)

Histone and nonhistone proteins from normal and virus-transformed rat thyroid epithelial cells.

PubMed (1987)

Vincenzo Giancotti B. Pani Paola D’Andrea Maria Teresa Berlingieri Pier Paolo Di Fiore

The histone and nonhistone nuclear proteins extracted by different methods from nuclei of normal and virus-transformed rat thyroid epithelial cells (FRTL5 cell line) were studied by polyacrylamide gel electrophoresis in acetic acid/urea and in SDS and by autoradiography. The results have shown that some of these proteins have an higher level of phosphorylation in virus-transformed than in normal cells; moreover, an higher amount of three proteins (C, D, and E), which in normal cells are not detectable at least as Coomassie staining, was found. These proteins, extractable with perchloric acid, are suggested to belong to the High Mobility Group (HMG proteins) and to play some regulatory role.

Coomassie Brilliant Blue

Non-histone protein

High-mobility group

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Supplementary Figure 2 from Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer

Pierlorenzo Pallante Antonio Federico Maria Teresa Berlingieri Mimma Bianco Angelo Ferraro

Supplementary Figure 2 from Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer

Expression (computer science)

10.1158/0008-5472.22376589.v1

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