Valeriy Myasoyedov

Kharkiv National Medical University

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Oleg A. Yeshchenko

Taras Shevchenko National University of Kyiv

Yuliia Kuziv

Taras Shevchenko National University of Kyiv

Dmytro Butov

Kharkiv National Medical University

Anatolii Onishchenko

Kharkiv National Medical University

Guochao Nie

Yulin Normal University

Nataliya Kutsevol

Taras Shevchenko National University of Kyiv

Sican Zhong

Yulin Normal University

Volodymyr Prokopіuk

Kharkiv National Medical University

Anton Tkachenko

Kharkiv National Medical University

Pavlo Virych

Taras Shevchenko National University of Kyiv

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Taras Shevchenko National University of Kyiv

Kharkiv National Medical University

Institute for Problems of Cryobiology and Cryomedicine

National Academy of Sciences of Ukraine

Institut Charles Sadron

Université de Strasbourg

Centre National de la Recherche Scientifique

Yulin Normal University

Shenzhen University

Research Center Borstel - Leibniz Lung Center

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Cytotoxicity of Hybrid Noble Metal-Polymer Composites

BioMed Research International (2022)

Anton Tkachenko Pavlo Virych Valeriy Myasoyedov Volodymyr Prokopіuk Anatolii Onishchenko

The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca2+-mediated pathways at the low concentration, in contrast to other studied materials. Thus, the cytotoxicity of Ag/D-PAA composite against erythrocytes was more pronounced compared with D-PAA and hybrid Au/polymer composite. Eryptosis is a more sensitive tool for assessing the biocompatibility of nanomaterials compared with fibroblast viability assays.

Nanocarriers

Biocompatibility

Viability assay

Nanomaterials

Noble metal

Silver nanoparticle

10.1155/2022/1487024

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Citations (7)