G. Bennett Humphrey

Children with acute lymphoblastic leukemia were randomized to one of two treatment options for CNS prophylaxis. All patients received intrathecal therapy over a one-year period with methotrexate, hydrocortisone and cytosine arabinoside. One-half of the patients also received 2400 rad cranial radiation over 2 1/2 weeks. There was no significant difference in CNS relapse rate, length of hematologic remission or survival between the two groups. No further CNS relapses have been observed for the last four years. CNS relapse was associated with subsequent disease recurrence in the 67% of patients.

Prophylactic cranial irradiation

Acute lymphocytic leukemia

10.1002/1097-0142(19820915)50:6<1031::aid-cncr2820500602>3.0.co;2-7

Cite

Citations (49)

[Psychological care of chronically ill children with a progressive disease].

PubMed (1985)

Roland Nitschke Sexauer Cl Barbara E. Spencer G. Bennett Humphrey

Source

Cite

Citations (0)

Longitudinal anthropometric study in children with acute lymphoblastic leukaemia

Acta Paediatrica (1992)

RYJ Tamminga WA Kamps NM Drayer G. Bennett Humphrey

In four groups of patients with acute lymphoblastic leukaemia, anthropometric variables were investigated every 3 months for 2 years. Group 1 ( n = 7) was treated with a high‐risk protocol, group 2 ( n = 13) with a standard‐risk protocol including cranial irradiation, group 3 ( n = 13) with a standard‐risk protocol without cranial irradiation and group 4 ( n = 8) was followed after completion of treatment. A height retardation of 0.4–0.6 SD was observed during therapy in groups 1–3. A catch‐up of 0.5 SD was found in group 4. The retardation of armspan was significantly larger than the retardation of sitting height when groups 1–3 were taken together. Head circumference was not affected. The anthropometric variables reflecting nutritional status showed a growth above normal during and after treatment. Corticosteroid medication and not cranial irradiation is the most likely explanation for our findings.

10.1111/j.1651-2227.1992.tb12080.x

Cite

Citations (21)

Modified LSA2-L2 treatment in 53 children with E-rosette-positive T- cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study)

Blood (1982)

DJ Pullen MP Sullivan JM Falletta JM Boyett G. Bennett Humphrey

Regimen

White blood cell

10.1182/blood.v60.5.1159.1159

Cite

Citations (66)

960 THE ACCURACY OF IDENTIFYING T CELL LEUKEMIA USING E ROSETTING OF BONE MARROW LYMPHOBLASTS