Chuan Luo

China Resources (China)

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Zhenyuan Miao

Second Military Medical University

Wannian Zhang

Ningxia Medical University

Wei Guo

Jiangsu Provincial Party School

Jianjiang Ma

Shanghai Institute of Technology

Wenfeng Liu

Fudan University

Yuelin Wu

Shanghai Institute of Technology

Xiaoying Che

Guangzhou University of Chinese Medicine

Bo Gao

Shanghai Children's Medical Center

Jianzhong Yao

Second Military Medical University

Wei Tang

The University of Tokyo

Cooperative Institutions

Second Military Medical University

The University of Tokyo

Shanghai Institute of Technology

Chinese Academy of Sciences

Tokai University

China Pharmaceutical University

East China University of Science and Technology

Ministry of Education of the People's Republic of China

Anhui University of Traditional Chinese Medicine

Chinese Academy of Medical Sciences & Peking Union Medical College

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Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I

European Journal of Medicinal Chemistry (2010)

Wei Guo Zhenyuan Miao Chunquan Sheng Jianzhong Yao Hao Feng

Topotecan

IC50

Topoisomerase inhibitor

Cancer cell lines

10.1016/j.ejmech.2010.01.063

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Citations (19)

Discovery of Novel 3,11‐Bispeptide Ester Arenobufagin Derivatives with Potential in Vivo Antitumor Activity and Reduced Cardiotoxicity

Chemistry & Biodiversity (2023)

Wenmin Tang Yanming Zhang Keli Yang Jianjiang Ma Lian Dong

Abstract Arenobufagin, one of the bufadienolides isolated from traditional Chinese medicine Chan'su, exhibits potent antitumor activity. However, serious toxicity and small therapeutic window limits its drug development. In the present study, to our knowledge, novel 3,11‐bispeptide ester arenobufagin derivatives have been firstly designed and synthesized on the base of our previous discovery of active 3‐monopeptide ester derivative. The in vitro antiproliferative activity evaluation revealed that the moiety at C3 and C11 hydroxy had an important influence on cytotoxic activity and selectivity. Compound ZM350 notably inhibited tumor growth by 58.8 % at a dose 10 mg/kg in an A549 nude mice xenograft model. Therefore, compound ZM350 also presented a concentration‐dependent apoptosis induction and low inhibitory effect against both hERG potassium channel and Cav1.2 calcium channel. Our study suggests that novel 3,11‐bispeptide ester derivatives will be a potential benefit to further antitumor agent development of arenobufagin.

hERG

Cardiotoxicity

10.1002/cbdv.202200911

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Citations (1)

Corydalis tomentella Franch. Exerts anti-inflammatory and analgesic effects by regulating the calcium signaling pathway

Journal of Ethnopharmacology (2023)

Shuyi Jin Y. Li Chuan Luo Xinyi Cheng Wei Tao

10.1016/j.jep.2023.117499

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Citations (2)

Combination of Cinobufacini and Doxorubicin Increases Apoptosis of Hepatocellular Carcinoma Cells through the Fas- and Mitochondria-Mediated Pathways

The American Journal of Chinese Medicine (2017)

Jufeng Xia Yoshinori Inagaki Jianjun Gao Fanghua Qi Peipei Song

Cinobufacini, a traditional Chinese medicine, has been used widely for cancer treatment, such as hepatocellular carcinoma (HCC), sarcoma, and leukemia. Previous studies done by our lab indicated that cinobufacini could suppress HCC cells through mitochondria-mediated and Fas-mediated apoptotic pathways. Here, we use a combination of cinobufacini and doxorubicin to inhibit the growth of HCC cells. The combination group induced more significant apoptosis by affecting proteins and RNA of apoptosis-related elements, such as Bcl-2, Bax, Bid, and cytochrome c. Furthermore, cinobufacini, as a mixture of a number of components, had stronger apoptosis-inducing activity than particular individual components or a simple mixture of a few components. Overall, these results suggested that the combination of cinobufacini and doxorubicin may provide a new strategy for inhibiting the proliferation of HCC cells.

Liver Cancer

10.1142/s0192415x17500835

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Citations (38)

An aqueous extract from toad skin prevents gelatinase activities derived from fetal serum albumin and serum-free culture medium of human breast carcinoma MDA-MB-231 cells

Drug Discoveries & Therapeutics (2015)

Munehiro Nakata Shota Kawaguchi Ayami Oikawa Akito Inamura Shunki Nomoto

An aqueous extract from toad skin, cinobufacini, has been known to possess anticancer ability. The present study examined effect of toad skin extract on activity of gelatinases including matrix metalloproteinases-2 and -9 which play an important role in invasion of carcinoma cells. Gelatinase activities derived from fetal serum albumin and culture medium of human breast carcinoma cell line MDA-MB-231 were significantly prevented in the presence of toad skin extract. The inhibitory activity was found in water-soluble fraction of the extract prepared by the Bligh & Dyer method but not in CHCl(3)-soluble lipid fraction. These results suggest that an aqueous extract from toad skin contains a water-soluble substance possessing a potent ability to prevent gelatinase activity. In conclusion, the water-soluble substance in toad skin extract cinobufacini may be able to regulate cancer cell migration accelerated by matrix metalloproteinases.

Fetal bovine serum

Bovine serum albumin

10.5582/ddt.2015.01060

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Citations (8)

Phosphate ester derivatives of homocamptothecin: Synthesis, solution stabilities and antitumor activities

Bioorganic & Medicinal Chemistry (2010)

Zhenyuan Miao Jing Zhang You Liang Juan Wang Chunquan Sheng

Cancer cell lines

10.1016/j.bmc.2010.03.039

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Citations (20)