Paul Victor

SRM Institute of Science and Technology

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Kunka Mohanram Ramkumar

SRM Institute of Science and Technology

Goutham V. Ganesh

SRM Institute of Science and Technology

Vijay Viswanathan

India Diabetes Research Foundation

D. V. L. Sarada

SRM Institute of Science and Technology

Dhamodharan Umapathy

SRM Institute of Science and Technology

Leema George

Pushpagiri Medical College

Satyavani Kumpatla

India Diabetes Research Foundation

Murali Krishna Prasad

SRM Institute of Science and Technology

Karan Naresh Amin

SRM Institute of Science and Technology

Udyama Juttada

M.V. Hospital for Diabetes and Diabetes Research Centre

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SRM Institute of Science and Technology

M.V. Hospital for Diabetes and Diabetes Research Centre

SRM University

India Diabetes Research Foundation

Anna University, Chennai

Karpagam Academy of Higher Education

Institute of Medical Sciences

Saveetha University

Pushpagiri Medical College

University of Tennessee Health Science Center

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Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1

European Journal of Pharmacology (2020)

Paul Victor D. V. L. Sarada Kunka Mohanram Ramkumar

Proteostasis

10.1016/j.ejphar.2020.173749

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Pharmacological activation of Nrf2 promotes wound healing

European Journal of Pharmacology (2020)

Paul Victor D. V. L. Sarada Kunka Mohanram Ramkumar

Homeostasis

10.1016/j.ejphar.2020.173395

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Citations (65)

Sodium‐Glucose Cotransporter‐2 Inhibitor Suppresses Endoplasmic Reticulum Stress and Oxidative Stress in Diabetic Nephropathy Through Nrf2 Signaling: A Clinical and Experimental Study

The Journal of Clinical Pharmacology (2024)

Murali Krishna Prasad Paul Victor Goutham V. Ganesh Udayama Juttada Satyavani Kumpatla

Abstract Diabetic nephropathy (DN), a severe complication of type 2 diabetes mellitus (T2DM), is marked by heightened endoplasmic reticulum stress (ERS) and oxidative stress (OS) due to protein misfolding and free radical generation. We investigated the sodium‐glucose co‐transporter‐2 inhibitor (SGLT2i), canagliflozin (Cana), in alleviating ERS and OS in DN patients and THP‐1 cells under hyperglycemic condition. A total of 120 subjects were divided into four groups, with 30 subjects in each group: healthy controls, T2DM individuals, DN patients receiving standard treatment, and those treated with Cana. The control group had no history of diabetes, cardiovascular or renal diseases, or other comorbidities. Cana was administered at doses of either 100 or 300 mg per day based on the estimated glomerular filtration rate (eGFR) value of DN individuals, with a mean follow‐up of 6 months. Additionally, THP‐1 monocytes were exposed to HGM (33.3 mM glucose with a cytokine cocktail of TNF‐α and IFN‐γ at 50 ng/mL each) to evaluate the relative levels of ERS, OS markers, and nuclear factor erythroid 2‐related factor 2 (Nrf2), the transcription factor regulating cellular redox, which is downregulated in diabetes. Our results revealed that ERS markers GRP78 and PERK, as well as OS markers TXNIP and p22phox, were elevated in both DN patients and HGM‐treated THP‐1 monocytes and were reduced by Cana intervention. Furthermore, Cana regulated the phosphorylation of Nrf2, Akt, and EIF2α in HGM‐treated monocytes. In conclusion, our findings highlight the role of Cana in activating Nrf2, thereby attenuating ERS and OS to mitigate DN progression.

P22phox

Canagliflozin

10.1002/jcph.2465

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Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy

Cell Stress and Chaperones (2020)

Paul Victor Dhamodharan Umapathy Leema George Udyama Juttada Goutham V. Ganesh

Crosstalk

10.1007/s12192-020-01176-z

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Citations (46)