Longhai Yang

Shenzhen University

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Yousheng Mao

Chinese Academy of Medical Sciences & Peking Union Medical College

Zizi Zhou

Shenzhen Third People’s Hospital

Bo Ye

Wuhan University of Technology

Xiangyang Liu

Dalian Medical University

Chuanduo Zhao

Chinese Academy of Medical Sciences & Peking Union Medical College

Shujun Cheng

Chinese Academy of Medical Sciences & Peking Union Medical College

Ting Xiao

Chinese Academy of Medical Sciences & Peking Union Medical College

Hui-Yu Pan

Beijing National Laboratory for Molecular Sciences

Ke Ma

Northwest A&F University

Jun‐Yu Xu

Chinese Academy of Sciences

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Shanghai Jiao Tong University

The University of Texas MD Anderson Cancer Center

Peking Union Medical College Hospital

University of Chinese Academy of Sciences

Capital Medical University

Peking University

Central South University

Southern Medical University

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Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients

Frontiers in Oncology (2020)

Lulu Pan Xijun Wang Longhai Yang Lei Zhao Linhui Zhai

Lung squamous cell carcinoma (LUSC) is one of the leading causes of tumor-driven deaths in the world. To date, studies on the tumor heterogeneity of LUSC at genomic level have only revealed limited therapeutic benefits. Therefore, system-wide research of LUSC at proteomic level may further improve precision medicine strategies on individual demands. To this end, we performed proteomic and phosphoproteomic study for LUSC samples of 25 Chinese patients. From our results, two subgroups (Cluster I and II) based on proteomic data were identified, which were associated with distinct molecular characteristics and clinicopathologic features. Combined with phosphoproteomic data, our result showed that spliceosome pathway was enriched in Cluster I, while focal adhesion pathway, immune-related pathways and Ras signaling pathway were enriched in Cluster II. In addition, we found that lymph node metastasis (LNM) was associated with our proteomic subgroups and cell cycle pathway was enriched in patients with LNM. Further analysis showed that MCM2, a DNA replication licensing factor involved in cell cycle pathway, was highly expressed in patients with poor prognosis, which was further proved by immunohistochemistry (IHC) analysis. In summary, our study provided a resource of the proteomic and phosphoproteomic features of LUSC in Chinese patients.

10.3389/fonc.2020.00963

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Successful resolution of ectopic Cushing syndrome by minimally invasive thoracoscopic resection of the neuroendocrine tumor of the thymus: a rare case report

BMC Surgery (2022)

Zizi Zhou Wenxiang Chai Longhai Yang Yi Liu Yao Liu

Abstract Background Ectopic Cushing syndrome (ECS) is a sporadic condition. Even uncommon is an ECS that derives from a carcinoid tumor of the thymus. These tumors may pose several diagnostic and therapeutic conundrums. This report discusses the differential diagnosis, clinicopathological findings, and effective treatment of a rare case of ECS using a minimally invasive approach. Case presentation A 29-year-old woman with Cushing syndrome presented with facial flushing. Physical examination revealed hypertension (blood pressure: 141/100 mmHg). A mediastinal tumor was discovered to be the cause of the patient’s chronic hypokalemia and hypercortisolemia. Cortisol levels increased in the morning, reaching 47.7 ug/dL. The levels of the hormones ACTH, aldosterone, and renin were determined to be 281 pg/mL, 3.0 ng/dL, and 2.1 pg/mL, respectively. The presence of hypertension, hypokalemia, and alkalinity suggested Cushing’s syndrome, which was proven to be ACTH-dependent ECS by a dexamethasone suppression test. A chest CT scan revealed inflammation in the posterior basal region of the right lower lobe. The superior anterior mediastinum was characterized by round-shaped isodensity lesions with distinct borders. She underwent thoracoscopic anterior mediastinal tumor excision via the subxiphoid technique (R0 resection); following surgery, her blood pressure returned to normal, and the hypernatremia/hypopotassemia resolved. The tumor was determined to be a thymic carcinoid. Most notably, cortisol levels fell to half of their presurgical levels after one hour of surgery, and other abnormalities corrected substantially postoperatively. Conclusion Thoracoscopic excision of thymic tumors by subxiphoid incision may be a useful treatment option for ECS caused by neuroendocrine tumors of the thymus

Thoracoscopy

10.1186/s12893-022-01674-0

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Multiple organ metastases of pulmonary epithelioid haemangioendothelioma and a review of the literature

Medical Oncology (2009)

Bo Ye Wang Li Xiangyang Liu Ke-Ling Sun Longhai Yang

Rare disease

Hematology

10.1007/s12032-009-9169-0

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Endotracheal and Endobronchial Metastases in a Patient With Stage I Lung Adenocarcinoma

The Annals of Thoracic Surgery (2014)

Zhirong Zhang Yousheng Mao Huang Chen Jingsi Dong Longhai Yang

10.1016/j.athoracsur.2013.09.064

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Citations (15)

[Clinical analyses of surgical treatment for lung metastatic tumors].

PubMed (2015)

Liang Zhao Longhai Yang Baihua Zhang Jiagen Li Zhirong Zhang

To evaluate the distribution, diagnosis, indication and modus operandi of surgical treatment and prognostic factors for patients with lung metastatic tumors.The clinical features were collected for 329 surgical patients with lung metastatic tumors during March 1998 and December 2013. Survival analysis was also performed by Log-rank test and Cox-regression analysis.The origins were epithelial tissue tumors (n = 278), sarcomas (n = 32), germ cell tumors (n = 3), malignant melanoma (n = 3) and miscellaneous tumors (n = 13). Their 1, 3 and 5-year survival rates were 85.1％, 50.9％ and 37.1％ respectively with a median survival time of 38 months. Log-rank survival analysis showed that resection extent (P = 0.004), lymph node dissection (P = 0.017) and radical operation (P < 0.01) were significantly associated with patient survival. And multi-variable Cox-regression analysis showed that lymph node dissection and radical operation were two independent prognostic factors.For lung metastatic tumor patients with well-controlled primary malignancy and non-metastasis of other organs, radical resection should be performed with minimal resection extent. And routine systematic lymph node dissection is not recommended. The necessity of lymph node dissection should be determined by radiological evaluations and surgical explorations.

Surgical oncology

Primary tumor

Prognostic variable

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Integrative Proteomic Characterization of Human Lung Adenocarcinoma

Cell (2020)

Jun‐Yu Xu Chunchao Zhang Xiang Wang Linhui Zhai Yiming Ma

Human lung

10.1016/j.cell.2020.05.043

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Citations (441)

[OLC1 protein levels in plasma of patients with non-small cell lung cancer and its clinical application].

Zhonghua zhongliu zazhi (2014)

Longhai Yang Ting Xiao Jinjing Tan Shiping Chen Yanning Gao

10.3760/cma.j.issn.0253-3766.2014.05.009

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Surgical Treatment of Tracheal Lipoma after Multiple Bronchoscopy Interventions and Placements of a Tracheal Stent

The Thoracic and Cardiovascular Surgeon Reports (2019)

Xiaoming Zhang Tao Ji Longhai Yang Yi Liu Hongsheng Lin

Background The majority of adult primary tracheal tumors are malignant; however, as one type of benign tumors, lipoma is extremely uncommon. Case Description We report a case where lipoma was first misdiagnosed as bronchial asthma, followed by sudden aggravation of dyspnea after trauma, and computed tomography (CT) examination of the neck and chest confirmed a tracheal tumor. Through multiple bronchoscopy interventions and placements of a tracheal stent, little therapeutic benefit was discovered, and resection of the tracheal tumor combined with tracheal end-to-end anastomosis was performed to ultimately achieve a cure. Conclusion Primary tracheal tumors should be highly suspected in patients with recurrent and gradually worsening dyspnea; timely cervical, thoracic CT and bronchoscopy can provide an accurate diagnosis. Surgical radical resection is the only way to cure all benign tracheal tumors such as lipoma.

10.1055/s-0039-1688903

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Citations (5)

Lysyl Oxidase-Like Protein-2 Silencing Suppresses the Invasion and Proliferation of Esophageal Cancer Cells

Journal of Biomaterials and Tissue Engineering (2022)

Yi Liu Jinfeng Zhu Longhai Yang Qiang Wu Zizi Zhou

This study explores the effect of silencing lysyl oxidase-like protein-2 (LOXL2) gene on TE-1 cells. TE-1 cells were transfected by LOXL2-siRNA. E-cadherin, LOXL2, and Snail were detected using Western blot and Real-time PCR. Transwell invasion and migration assay was performed. Flow cytometry detected apoptosis. Cell growth was analyzed with CCK-8 and colony formation. After48 h of transfection, compared with control groups, LOXL2 mRNA in the LOXL2-siRNA group (0.40±0.01) lowered significantly ( P < 0.05). Consistently, LOXL2 protein in LOXL2-siRNA group was (0.48± 0.02), significantly lower than that in blank control (1.04± 0.03) and negative control (1.02± 0.02) ( P < 0.05). After 72 h of cell culture, the absorbance of LOXL2-siRNA group was (0.43±0.04), which reduced significantly than blank control (0.81±0.05) and negative control (0.84±0.06) ( P < 0.05). Similarly, cell clone number after LOXL2-siRNA transfection (72.3±4.2)increased significantly than the negative control (178.8±4.6) and blank control (167.3±3.5) ( P < 0.05). However, LOXL2 silencing did not significantly affect cell apoptosis. Furthermore, LOXL2 silencing inhibited Snail while increased E-cadherin ( P < 0.05). Conclusively, LOXL2 silencing may suppress the invasion and proliferation of esophageal cancer cells via down-regulating Snail, and up-regulating E-cadherin to inhibit EMT in esophageal cancer cells.

Lysyl Oxidase

10.1166/jbt.2022.3082

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[Clinical data analysis on 43 cases of the giant lymph node hyperplasia].

PubMed (2009)

Bo Ye Wang Li Longhai Yang Ke Ma Xiangyang Liu

To summarize the clinical features, treatment and prognosis of giant lymph node hyperplasia (Castleman's disease, CD).The clinical data of 43 CD patients with the tumor located in neck (n = 10), chest (n = 20), abdomen (n = 9) and multi-centers (n = 4) were analyzed.All the patients underwent surgical resection of tumor or lymph and the patients of multicentric disease underwent adjuvant chemotherapy or radiotherapy. All the diagnoses of CD were confirmed by pathological examination. Among all the cases, 26 patients were hyaline vascular subtype (HV), 16 patients plasma cell subtype (PC) and 1 patient mixed subtype. All 39 patients of unicentric disease survived without disease evidence. 2 patients of multicentric disease died at 18 months and 54 months after surgery; 1 patient survived with disease; 1 patient survived with no evidence of disease.Giant lymph node hyperplasia is a rare disease. The diagnosis depends mainly on the pathological examination. Surgery is the best choice for unicentric disease with an excellent prognosis. Patients with multicentric disease may benefit from surgery, adjuvant chemotherapy or radiotherapy, but the prognosis remains grim.

Adjuvant Therapy

Hyaline

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