Massimo Marconi

Ospedale San Giuseppe

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Co-Authors

Maria Antonietta Avanzini

Istituti di Ricovero e Cura a Carattere Scientifico

Rita Maccario

Istituti di Ricovero e Cura a Carattere Scientifico

Gian Luigi Marseglia

Policlinico San Matteo Fondazione

Franco Locatelli

Università Cattolica del Sacro Cuore

Anna Maria Castellazzi

University of Pavia

Alberto G. Ugazio

Bambino Gesù Children's Hospital

Antonella Gasparoni

University of Brescia

Daniela Montagna

Policlinico San Matteo Fondazione

A. G. Siccardi

Istituti di Ricovero e Cura a Carattere Scientifico

G Rondini

Universidad Nacional de La Pampa

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

135

University of Pavia

114

Policlinico San Matteo Fondazione

University of Brescia

University of Milan

Bambino Gesù Children's Hospital

Istituto Giannina Gaslini

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

University of Bologna

University of Genoa

Author Statistics

Papers

Citation

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Research Field

Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease

Cytotherapy (2009)

Maria Ester Bernardo Maria Antonietta Avanzini Rachele Ciccocioppo Cesare Perotti Angela Cometa

10.1080/14653240903121260

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Citations (7)

Subject Index

Neonatology (1992)

Sreerama Shetty Sharan Hegde Mami Ohsugi Hiroshi Satō Hideki Yamamura

Birth asphyxia 24B Blood flow 258 Body length 317 -weight 317 Bombesin antagonist 395 Bone formation 23 -mass 23 -resorption 23 Brain 215 -development 193 -evoked potentials 265 -injury 231.243.

10.1159/000327437

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Citations (0)

Staphylocidal defect of polymorphonuclear leukocytes in a patient with Leprechaunism

European Journal of Pediatrics (1981)

F Sacchi Giuseppe Maggiore Elena Bianchi Gian Luigi Marseglia Massimo Marconi

Abnormality

10.1007/bf00441177

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Citations (3)

Affective temperaments are associated with specific clusters of symptoms and psychopathology: A cross-sectional study on bipolar disorder inpatients in acute manic, mixed, or depressive relapse

Journal of Affective Disorders (2013)

Felice Iasevoli Alessandro Valchera E. Di Giovambattista Massimo Marconi Maria Paola Rapagnani

Cross-sectional study

Child psychopathology

10.1016/j.jad.2013.06.041

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Citations (51)

Multiple inhibitors of mitogen-induced proliferation of normal lymphocytes in juvenile chronic arthritis sera.

PubMed (1990)

Fabrizio De Benedetti Massimo Marconi Angelo Ravelli D Goggi Rita Maccario

We evaluated the effect of 47 serum samples obtained from 34 children with juvenile chronic arthritis (JCA) on mitogen-induced proliferation of normal peripheral blood lymphocytes (nPBL). We found that sera from patients with active disease, and particularly those with the systemic form, inhibited significantly PHA-induced proliferation of nPBL at all the PHA concentrations tested. This inhibitory activity was independent of the treatment and was correlated with the value of the erythrocyte sedimentation rate. Part of the JCA sera inhibitory effect could be reversed by the addition of exogenous interleukin 2 (IL-2), but not of interleukin 1 (IL-1) or interferon-gamma, moreover, JCA sera were able to partially inhibit the IL-2 dependent proliferation of CTLL. When we tested serum fractions obtained by Sephadex G-200 chromatography for their inhibitory activity, we observed that: a) two major peaks of inhibitory activity on PHA-induced proliferation were present: peak 1 with MW less than 600,000 and peak 2 with MW between 70,000 and 35,000; b) the inhibitory activity present in the high MW peak was in part IL-2 related; and c) both peaks contained elevated levels of acute phase proteins (APP) which are known to inhibit mitogen-induced lymphocyte proliferation. We conclude that sera from patients with active systemic JCA contain inhibitory activity on mitogen-induced lymphocyte proliferation. We conclude that sera from patients with active systemic JCA contain inhibitory activity on mitogen-induced lymphocyte proliferation. This activity is due to the presence of multiple inhibitors, one of which appears to be IL-2 related; at least part of the inhibitory activity may be due to elevated serum levels of APP.

Sephadex

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Citations (3)

Human Mesenchymal Stem Cells Inhibit In Vitro Antibody Production Against Alloantigens.

Blood (2005)

Patrizia Comoli Rita Maccario Maria Antonietta Avanzini Fabrizio Ginevri Antonia Moretta

10.1182/blood.v106.11.3033.3033

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Citations (0)

[Anesthesia and the chemotaxis of neutrophilic granulocytes in newborn infants].

PubMed (1990)

De Amici D Antonella Gasparoni G Coven G. Mingrat Massimo Marconi

The authors investigated the modifications of neutrophil chemotaxis and cortisol plasma levels in the newborn delivered by cesarean section or vaginal delivery. Chemotaxis turned out to be higher in the group undergoing cesarean section, while cortisol was lower in this group. The increased activity of neutrophils can be explained with the lessened inhibitory effect of endogenous steroids and with the stimulating action of nitrous oxide.

Nitrous oxide

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Citations (1)

In vivo Activated Cord Blood Lymphocytes Express High Affinity lnterleukin-2 Receptor: Evaluation of Their Responsiveness to in vitro Stimulation with Recombinant lnterleukin-2

Neonatology (1992)

Daniela Montagna Antonia Moretta Massimo Marconi G. Mingrat Antonella Gasparoni

We report the phenotypical and functional characterization of a cord blood mononuclear lymphocyte subset (CBMC) which expresses the p55 chain of interleukin-2 receptor (IL-2R, CD25). The great majority of CD25-positive CBMC are activated CD3-positive T lymphocytes in that most of them are HLA-DR-positive, coexpress both CD4 and CD8 antigens and at least a part of them display high affinity IL-2R. In keeping with the expression of both chains of IL-2R (p55 and p75), enriched CD25-positive CBMC are able to display strong IL-2-induced proliferation and lymphokine-activated killing activity. The percentage of CD25-positive cells is higher in cord blood than in adult peripheral blood and their presence could be peculiarly important in the neonatal period, when specific T-cell-mediated immune responses are still on their way to full maturation.

Cord blood

10.1159/000243896

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Citations (8)

[Pleuropulmonary aspects of rheumatic disease].

PubMed (1980)

M Livadiotti Cannavò Rc Putnieks IaIa Massimo Marconi

Rheumatic disease

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Citations (0)

Children with recurrent otitis show defective IFNγ‐producing cells in adenoids

Pediatric Allergy and Immunology (2008)

Maria Antonietta Avanzini Anna Maria Castellazzi Massimo Marconi Chiara Valsecchi Alessia Marseglia

Infectious diseases are frequently observed in children and their recurrence represents a demanding challenge for the paediatrician. It has been hypothesized that a defective immune response may occur in these patients. The aim of the present study was to evaluate whether children presenting with recurrent otitis have a defective interferon (IFN)gamma production by the lymphocytes of peripheral blood and of adenoid tissue, in comparison with children without recurrent otitis. Our study group was represented by 58 children undergoing adenoidectomy for adenoidal hypertrophy. They were subdivided into two groups according to the recurrence of otitis (>or=3 per year) or not (<3 per year). Intracellular cytokine profile of lymphocyte subsets in adenoids and peripheral blood was evaluated by flow cytometry analysis. Children with recurrent otitis showed a significantly lower percentage of CD8+-producing IFN gamma cells in adenoids than children with <3 otitis per year (p = 0.003). The reduced capability of the adenoid cells to produce INF-gamma may induce a high susceptibility to the recurrence of otitis in children.

Adenoid

Adenoid hypertrophy

10.1111/j.1399-3038.2007.00682.x

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Citations (19)