Jing-Bo Yang

University of Science and Technology of China

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Qi Miao

Huazhong University of Science and Technology

Wen-Tao Ma

University of Science and Technology of China

Yuan Yao

National Cancer Institute

Kai Yan

Yangzhou University

Zhi-Bin Zhao

Guangdong Academy of Medical Sciences

M. Eric Gershwin

University of California, Davis

Qing-Zhi Liu

South China University of Technology

Liang Li

First Affiliated Hospital of Xinjiang Medical University

Zhe-Xiong Lian

South China University of Technology

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University of Science and Technology of China

South China University of Technology

Guangzhou First People's Hospital

Guangzhou Medical University

Guangdong Academy of Medical Sciences

Guangdong Provincial People's Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

University of California, Davis

Huazhong University of Science and Technology

Union Hospital

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The CXC Chemokine Receptor 3 Inhibits Autoimmune Cholangitis via CD8+ T Cells but Promotes Colitis via CD4+ T Cells

Frontiers in Immunology (2018)

Qing-Zhi Liu Wen-Tao Ma Jing-Bo Yang Zhi-Bin Zhao Kai Yan

CXC chemokine receptor 3 (CXCR3), a receptor for the C-X-C motif chemokines (CXCL) CXCL9, CXCL10, and CXCL11, which not only plays a role in chemotaxis but also regulates differentiation and development of memory and effector T cell populations. Herein, we explored the function of CXCR3 in the modulation of different organ-specific autoimmune diseases in interleukin (IL)-2 receptor deficiency (CD25-/-) mice, a murine model for both cholangitis and colitis. We observed higher levels of CXCL9 and CXCL10 in the liver and colon and higher expression of CXCR3 on T cells of the CD25-/- mice compared with control animals. Deletion of CXCR3 resulted in enhanced liver inflammation but alleviated colitis. These changes in liver and colon pathology after CXCR3 deletion were associated with increased numbers of hepatic CD4+ and CD8+ T cells, in particular effector memory CD8+ T cells, as well as decreased T cells in mesenteric lymph nodes and colon lamina propria. In addition, increased interferon-γ response and decreased IL-17A response was observed in both liver and colon after CXCR3 deletion. CXCR3 modulated the functions of T cells involved in different autoimmune diseases, whereas the consequence of such modulation was organ-specific regarding to their effects on disease severity. Our findings emphasize the importance of extra caution in immunotherapy for organ-specific autoimmune diseases, as therapeutic interventions aiming at a target such as CXCR3 for certain disease could result in adverse effects in an unrelated organ.

CXCL9

CXC chemokine receptors

CXCL16

10.3389/fimmu.2018.01090

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