S. B. Miguel

Centre for Biomedical Network Research on Rare Diseases

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Hélio G. Bonacorso

Universidade Federal de Santa Maria

Nilo Zanatta

Universidade Federal de Santa Maria

Marcos A. P. Martins

Universidade Federal de Santa Maria

Ademir F. Morel

Universidade Federal de Santa Maria

Federico Becerra-Aparicio

Instituto Ramón y Cajal de Investigación Sanitaria

Israel Orman

Centre for Biomedical Network Research on Rare Diseases

Izabella Thaís Silva

Universidade Federal de Santa Catarina

Claudia A. Cazaux

Consejo Nacional de Investigaciones Científicas y Técnicas

Oscar Quintana‐Bustamante

Hospital Universitario Fundación Jiménez Díaz

Fernando Durán

University of Buenos Aires

Cooperative Institutions

Universidade Federal de Santa Maria

Universidade Federal de Santa Catarina

Centre for Biomedical Network Research on Rare Diseases

Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas

Universidad Autónoma de Madrid

Hospital Universitario Fundación Jiménez Díaz

Centro de Investigación Biomédica en Red

Instituto de Salud Carlos III

Polydoro Ernani de São Thiago University Hospital

Universidade Estadual de Campinas (UNICAMP)

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Estrogens Enhance Human Hematopoietic Stem Cell Engraftment in a Xenogenic Transplantation Model

Blood (2018)

Sara Fañanas-Baquero Israel Orman Federico Becerra-Aparicio S. B. Miguel Jordi Garcia Merino

Homing (biology)

Hematopoietic stem cell

10.1182/blood-2018-99-112104

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Citations (0)

Increased proliferative activity, loss of β-adrenergic receptor function and class I major histocompatibility complex antigen surface expression in a modified lymphoma cell line

Cellular Signalling (1994)

Graciela Cremaschi S. B. Miguel Claudia A. Cazaux Leonor Sterin‐Borda

10.1016/0898-6568(94)00036-0

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Citations (6)

Reduced number and coupling of β-adrenergic receptors in a modified S49 mouse lymphoma cell line

International Journal of Immunopharmacology (1994)

Graciela Cremaschi Claudia A. Cazaux S. B. Miguel Leonor Sterin‐Borda

10.1016/0192-0561(94)90084-1

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Citations (1)

¹H and¹³C NMR Chemical Shifts and N-Substituent Effects of Some Unsymmetrically N,N-Disubstituted Acetamides

Spectroscopy Letters (1993)

Hélio G. Bonacorso S. B. Miguel Nilo Zanatta Marcos A. P. Martins

Abstract The 1H and 13C NMR chemical shift assignments of a series of (E) - and (Z)-N,N-Dialkylacetamides [CH3C(O)NR1R2, with R1/R2=Me/Et (1), Me/n-Bu (2), Et/n-Bu (3), Et/t-Bu (4), Me/Hydrcxyethyl (5)., Et/Hydroxyethyl (6), Et/Acetylhydroxyethyl (7)] are reported. The 1H chemical shifts for the N-substituents of the amides 1–7 recorded in benzene-d6 and in chloroform-d1 are in agreement with the Hatton and Richards (ASIS) and Paulsen-Todt models, respectively. The 13C chemical shifts for the N-substituents of compounds 1–3 were compared with data of the corresponding symmetrical amides, and the results can be explained by the reciprocal steric compression effect of one N-substituent on the other. The validity of this explanation is confirmed by 13C spin-lattice relaxation time (T1) measurements.

Chemical shift

Carbon-13

10.1080/00387019308011617

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Citations (1)

ChemInform Abstract: The First Application of 4‐Alkoxy‐1,1,1‐trifluoroalk‐3‐en‐2‐ones in a Three‐Component Condensation Protocol for the Synthesis of 3‐Acyl‐4‐aryl‐2‐ (trifluoromethyl)‐2‐hydroxy‐3,4,7,8‐tetrahydro‐2H‐chromen‐5(6H)‐ones.

ChemInform (2011)

Hélio G. Bonacorso Jussara Navarini Carson W. Wiethan Guilherme P. Bortolotto Gisele R. Paim

Abstract All products are purified by recrystallization and subsequent drying in a desiccator under reduced pressure over phosphorous pentoxide.

Recrystallization (geology)

Component (thermodynamics)

10.1002/chin.201132122

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Citations (2)

Influence of melatonin on the order of phosphatidylcholine-based membranes

Journal of Pineal Research (2010)

Vânia Rodrigues de Lima S. B. Miguel Maximiliano Luis Munford Bernard Desbat Érick J. Dufourc

Abstract: The effect of melatonin was evaluated on three phosphatidylcholine-based membrane models. Changes in liposome dynamics were monitored by fluorescence, following the response of the probe merocyanine-540, as well as by differential scanning calorimetry (DSC). Langmuir monolayers were investigated using molecular area measurements, as well as by Brewster angle microscopy (BAM). Mica-supported bilayers were observed via atomic force microscopy (AFM). Fluorescence results demonstrating that melatonin increases the affinity between MC-540 and lipid molecules possibly because of an increase in the membrane fluidity in liposomes. DSC analyses showed that melatonin promoted a reduction in enthalpy in the lipid nonpolar chains. Melatonin also promoted an increase in the molecular area of Langmuir monolayers, as well as a decrease in membrane thickness. Consequently, melatonin appeared to induce re-ordering effects in liposome and Langmuir monolayers. AFM images of bilayers immobilized on mica suggested that melatonin induced a gel state predominance or a delay in the main phase transition. At experimental conditions, melatonin interacted actively with all membranes models tested and induced changes in their physico-chemical properties. The data presented here may contribute to the understanding of melatonin physiologic properties, as well as the development of therapeutic advanced systems, such as drug delivery systems and biosensors.

Dipalmitoylphosphatidylcholine

10.1111/j.1600-079x.2010.00782.x

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Citations (57)

Effect of carbonyl substituents on the barrier to rotation in N‐ethyl‐N‐methylamides

Magnetic Resonance in Chemistry (1993)

Hélio G. Bonacorso S. B. Miguel Nilo Zanatta Marcos A. P. Martins

Abstract The barriers to rotation about the C(O)N bond for 13 α‐alkyl‐ and α‐halo‐substituted N ‐theyl‐ N ‐methylamides were determined by 1 H NMR spectroscopy at coalescence temperature. Plots of Gibbs free energy (Δ G °) and Gibbs energy of activation (Δ G ‡) values against Charton's electronic and steric parameters of the α‐carbonyl groups allows the conclusion that both the isomeric preference and the barrier to rotation about the C(O)N bond of the N ‐ethyl‐ N ‐methylamides depend mainly on the steric effect of the α‐carbonyl group.

Electronic effect

Steric factor

Internal Rotation

10.1002/mrc.1260310507

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Citations (6)

Synthesis of novel O-acylated-D-ribono-1,5-lactones and structural assignment supported by conventional NOESY-NMR and x-ray analysis

Journal of the Brazilian Chemical Society (2008)

Marcus M. Sá Gustavo P. Silveira S. B. Miguel Javier Ellena

A practical method for the structural assignment of 3,4-O-benzylidene-D-ribono-1,5-lactones and analogues using conventional NMR techniques and NOESY measurements in solution is described. 2-O-Acyl-3,4-O-benzylidene-D-ribono-1,5-lactones were prepared in good yields by acylation of Zinner’s lactone with acyl chlorides under mildly basic conditions. Structural determination of 2-O-(4-nitrobenzoyl)-3,4-O-benzylidene-D-ribono-1,5-lactone was achieved by single crystal x-ray diffraction, which supports the results based on spectroscopic data.

10.1590/s0103-50532008000100004

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Citations (6)

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

Haematologica (2020)

Sara Fañanas-Baquero Israel Orman Federico Becerra-Aparicio S. B. Miguel Jordi Garcia Merino

Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells. These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal and differentiation. However, this balance is altered during the hematopoietic recovery after Hematopoietic Stem and Progenitor Cell Transplantation. Transplantation efficacy can be limited by inadequate Hematopoietic Stem Cells number, poor homing, low level of engraftment, or limited self-renewal. As recent evidences indicate that estrogens are involved in regulating the hematopoiesis, we sought to examine whether natural estrogens (estrone or E1, estradiol or E2, estriol or E3 and estetrol or E4) modulate human Hematopoietic Stem and Progenitor Cells. Our results show that human Hematopoietic Stem and Progenitor Cell subsets express estrogen receptors, and whose signaling is activated by E2 and E4 on these cells. Additionally, these natural estrogens cause different effects on human Progenitors in vitro. We found that both E2 and E4 expand human Hematopoietic Stem and Progenitor Cells. However, E4 was the best tolerated estrogen and promoted cell cycle of human Hematopoietic Progenitors. Furthermore, we identified that E2 and, more significantly, E4 doubled human hematopoietic engraftment in immunodeficient mice without altering other Hematopoietic Stem and Progenitor Cells properties. Finally, the impact of E4 on promoting human hematopoietic engraftment in immunodeficient mice might be mediated through the regulation of mesenchymal stromal cells in the bone marrow niche. Together, our data demonstrate that E4 is well tolerated and enhances human reconstitution in immunodeficient mice, directly by modulating human Hematopoietic Progenitor properties and indirectly by interacting with the bone marrow niche. This application might have particular relevance to ameliorate the hematopoietic recovery after myeloablative conditioning, especially when limiting numbers of Hematopoietic Stem and Progenitor Cells are available.

Homing (biology)

Hematopoietic stem cell

10.3324/haematol.2019.233924

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Citations (15)

Scheme for preparation of a novel semisynthetic derivative of cucurbitacin B (DACE).

Izabella Thaís Silva Annelise De Carvalho Karen Luise Lang Sabine Eva Dudek Dörthe Masemann

Derivative (finance)

10.6084/m9.figshare.1308069

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Citations (0)