Shu‐Li You

Shanghai Institute of Organic Chemistry

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Chao Zheng

Chinese Academy of Sciences

190

Li‐Xin Dai

University of Hong Kong

121

Qing Gu

Chinese Academy of Sciences

108

Chao Zheng

Gannan Medical University

Chun‐Xiang Zhuo

Shanghai Institute of Organic Chemistry

Qing Gu

Illinois Institute of Technology

Xiǎo Zhang

Shanghai Jiao Tong University

Li-Xin Dai

Xue‐Long Hou

Shijiazhuang Tiedao University

Wen‐Bo Liu

Wuhan University

Cooperative Institutions

Chinese Academy of Sciences

271

Shanghai Institute of Organic Chemistry

206

University of Chinese Academy of Sciences

150

Fudan University

Peking University

Zhejiang University

Shanghai Jiao Tong University

Nankai University

Sichuan University

East China University of Science and Technology

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Regio‐ and Enantioselective Synthesis of N‐Allylindoles by Iridium‐Catalyzed Allylic Amination/Transition‐Metal‐Catalyzed Cyclization Reactions

Chemistry - A European Journal (2014)

Ke‐Yin Ye Li‐Xin Dai Shu‐Li You

Regio- and enantioselective synthesis of N-allylindoles was realized through an iridium-catalyzed asymmetric allylic amination reaction with 2-alkynylanilines and subsequent transition-metal-catalyzed cyclization reactions. The highly enantioenriched allylic amines prepared from Ir-catalysis were treated with catalytic amount of NaAuCl4⋅2 H2O or PdCl2 providing various substituted N-allylindoles in excellent yields and enantioselectivities.

10.1002/chem.201400026

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Citations (38)

Synthesis of 3-Haloindolizines by Copper(II) Halide Mediated Direct Functionalization of Indolizines

Organic Letters (2009)

Ji‐Bao Xia Shu‐Li You

3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizines. This C-H direct functionalization process occurred under mild conditions giving 3-haloindolizines in moderate to excellent yields, and the products obtained were tested under the Suzuki-Miyaura reaction providing 3-arylindolizines in high yields.

Surface Modification

10.1021/ol9000872

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Citations (56)

Iridium‐Catalyzed Asymmetric Allylic Etherification and Ring‐Closing Metathesis Reaction for Enantioselective Synthesis of Chromene and 2,5‐Dihydrobenzo[b]oxepine Derivatives

Advanced Synthesis & Catalysis (2012)

Hu He Ke‐Yin Ye Qing‐Feng Wu Li‐Xin Dai Shu‐Li You

Abstract Iridium‐catalyzed asymmetric etherifications of allylic carbonates with 2‐vinylphenols and 2‐allylphenols were realized. With a catalyst generated from 2 mol% of [Ir(cod)Cl] 2 (cod=cycloocta‐1,5‐diene) and 4 mol% of the phosphoramidite ligand L2 , the etherification products were obtained in excellent ee s and then subjected to the ring‐closing metathesis reaction providing an efficient synthesis of enantioenriched 2 H ‐chromene and 2,5‐dihydrobenzo[ b ]oxepine derivatives.

Salt metathesis reaction

Phosphoramidite

Ring-Closing Metathesis

Diene

10.1002/adsc.201100809

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Citations (56)

CCDC 2208536: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Jiahao Xie Yi-Ming Hou Zuolijun Feng Shu‐Li You

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2d453v

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Citations (0)

CCDC 2025685: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Qiang Wang Wen‐Wen Zhang Chao Zheng Qing Gu Shu‐Li You

10.5517/ccdc.csd.cc25zwpr

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(SCp)Rhodium‐Catalyzed Asymmetric Satoh–Miura Reaction for Building‐up Axial Chirality: Counteranion‐Directed Switching of Reaction Pathways

Angewandte Chemie (2022)

Wen‐Wen Zhang Qiang Wang Suzhen Zhang Chao Zheng Shu‐Li You

Abstract Satoh–Miura reaction is an important method for extending π‐systems by forging multi‐substituted benzene rings via double aryl C−H activation and annulation with alkynes. However, the development of highly enantioselective Satoh–Miura reaction remains rather challenging. Herein, we report an asymmetric Satoh–Miura reaction between 1‐aryl benzo[ h ]isoquinolines and internal alkynes enabled by a SCpRh‐catalyst. Judiciously choosing the counteranion of the Rh‐catalyst is crucial for the desired reactivity over the competitive formation of azoniahelicenes. Detailed mechanistic studies support the proposal of counteranion‐directed switching of reaction pathways in Rh‐catalyzed asymmetric C−H activation.

Reactivity

Reaction conditions

10.1002/ange.202214460

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Citations (2)

Asymmetric Dearomatization of β‐Naphthols through an Amination Reaction Catalyzed by a Chiral Phosphoric Acid

Angewandte Chemie (2014)

Shouguo Wang Qin Yin Chun‐Xiang Zhuo Shu‐Li You

Abstract A highly efficient catalytic asymmetric dearomatization of naphthols by means of an electrophilic amination reaction catalyzed by chiral phosphoric acid is presented. This protocol provides a facile access to functionalized β‐naphthalenone compounds with a chiral quaternary carbon center in excellent yields and enantioselectivity (up to 99 % yield, up to 96 % ee ).

Electrophilic amination

Phosphoric acid

Quaternary carbon

10.1002/ange.201409756

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Citations (45)

Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C–H Bond Arylation

Journal of the American Chemical Society (2014)

De‐Wei Gao Qin Yin Qing Gu Shu‐Li You

A highly efficient synthesis of planar chiral ferrocenes by enantioselective Pd(0)-catalyzed direct C-H arylation from readily available starting materials under mild reaction conditions was developed (up to 99% yield, 99% ee). The products can be easily transformed to the highly efficient planar ferrocene ligands, which have demonstrated high efficiency in Pd-catalyzed asymmetric allylic alkylation and amination reactions.

10.1021/ja500444v

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Citations (209)

Rhodium-Catalyzed Atroposelective C–H Alkylation of 1-Aryl Isoquinoline Derivatives with Cyclopropanols

ACS Catalysis (2025)

Wen‐Wen Zhang Quannan Wang Chao Zheng Shu‐Li You

Isoquinoline

10.1021/acscatal.5c00111

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Enantioselective Dearomatization of Indoles via SmI₂-Mediated Intermolecular Reductive Coupling with Ketones

Journal of the American Chemical Society (2023)

Wenyun Zhang Hu-Chong Wang Ye Wang Chao Zheng Shu‐Li You

Samarium diiodide (SmI2) mediated reductive coupling reactions are powerful methods for the construction of carbon-carbon bond in organic synthesis. Despite the extensive development in recent decades, successful examples of the corresponding asymmetric reactions remained scarce, probably due to the involvement of highly reactive radical intermediates. In this Article, we report an enantioselective dearomatization of indoles via SmI2-mediated intermolecular reductive coupling with ketones. The utilization of samarium reductant supported by chiral tridentate aminodiol ligands allows the facile synthesis of indoline molecules bearing two contiguous stereogenic centers in high yields (up to 99%) and stereoselectivity (up to 99:1 er and >20:1 dr). Combined experimental and computational investigations suggested that parallel single-electron transfer to each substrate from the chiral samarium reductant allows the radical-radical recombination in an enantioselective manner, which is a unique mechanistic scenario in SmI2-mediated reductive coupling reactions.

Stereocenter

Samarium diiodide

10.1021/jacs.3c01994

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Citations (16)