Hans-Joachim Selbitz

IDT Biologika (Germany)

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Thomas Lindner

Heidelberg University

Sven Springer

IDT Biologika (Germany)

Ralf Dürrwald

Robert Koch Institute

Uwe Truyen

Leipzig University

Thomas Lindner

Universität Hamburg

Roland Zell

Jena University Hospital

Uwe Rösler

Freie Universität Berlin

Andi Krumbholz

Kiel University

Michael Schlegel

University Hospital of Bern

Manfred Moos

Bundeswehrkrankenhaus

Cooperative Institutions

Leipzig University

University of Veterinary Medicine Hannover, Foundation

Institute of Medical Microbiology and Hygiene

Freie Universität Berlin

University of Veterinary Medicine Vienna

Ludwig-Maximilians-Universität München

IDT Biologika (Germany)

Friedrich Schiller University Jena

Jena University Hospital

Friedrich-Loeffler-Institut

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Impfungen gehört die Zukunft

veterinär spiegel (2015)

Hans-Joachim Selbitz

Die Eradikation von Tierseuchen ist nur ein Beispiel für die Ziele von Impfmaßnahmen. Angesichts der Bestrebungen, den Antibiotikaeinsatz in der Nutztierhaltung zu senken, werden Impfungen künftig weiter an Bedeutung gewinnen. Prof. Dr. Hans-Joachim Selbitz gibt einen Überblick über Anwendungsgebiete, Historie und aktuelle Trends.

10.1055/s-0034-1396233

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Citations (1)

Duration of immunity induced in chickens by an attenuated live Salmonella enteritidis vaccine and an inactivated Salmonella enteritidis/typhimurium vaccine.

PubMed (2011)

Sven Springer Thomas Lindner Mathias Ahrens Gerhard Woitow Francesco Prandini

The aim of this study was to examine the duration of immunity of different vaccination schemes using the S. enteritidis live vaccine Gallivac Se and the S. enteritidis-S. typhimurium inactivated vaccine Gallimune Se+St. Three groups of Lohman Brown chickens were used. Group one was vaccinated three times orally with Gallivac Se at weeks one, seven and 13 of age. Group two was vaccinated twice orally with Gallivac Se in weeks one and seven and once i.m. with Gallimune Se+St in week 14 of age. A third group was not vaccinated and served as the control group. Eight randomly selected chickens from each of the three groups were challenged with a nalidixic acid resistant S. enteritidis PT4 strain in weeks 24, 51 and 71 of age and the same number of animals were challenged with a S. typhimurium DT 104 strain in weeks 26, 54 and 73 (75) of age.The chickens were euthanised seven days post challenge and the number of challenge strain organisms (log10 cfu) in the liver and on caecal mucosa was determined.The quantitative investigation of the challenge strain in the liver and caecal mucosa revealed a statistically significant (p < 0.05) lower challenge strain burden in the vaccinated groups compared with the non-vaccinated control group up to week 71 (73) of age. The protective effects were demonstrated for both challenge strains.

Salmonella enteritidis

Attenuated vaccine

Strain (injury)

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Citations (17)

Antibody response after immunization with a Salmonella Typhimurium live vaccine in dependence on the way of application

Daniela Trepnau Evelyn Ulrich R Uhlig Thomas Lindner Hans-Joachim Selbitz

In Germany now, the recognition of Salmonella infections in pig herds is based on three different commercial tests detecting antibodies against Salmonella-derived lipopolysaccharide (LPS). However, a serious disadvantage of these tests, used so far, is the restricted detection of antibodies belonging predominantly to the immunoglobulin class g (IgG). Therefore, a new test was developed to detect three Ig classes (IgM, IgG and IgA). Different constellations between the three Ig classes allow the evaluation of the current infection status of each pig. Under field conditions, this was proved in three different vaccination trials using a commercial Salmonella Typhimurium live vaccine.

Herd Immunity

Attenuated vaccine

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Citations (3)

Swine Influenza A Vaccines, Pandemic (H1N1) 2009 Virus, and Cross-Reactivity

Emerging infectious diseases (2010)

Ralf Dürrwald Andi Krumbholz Sigrid Baumgarte Michael Schlegel Thomas W. Vahlenkamp

Infl uenza surge planning is premised on a high incidence of illness among elderly persons, but if the current pattern of illness continues, healthcare facilities also should prepare to treat younger persons who may constitute the bulk of cases.Additionally, studies of persons born during 1957-1968 should be conducted to quantify antibody levels to pandemic (H1N1) 2009 virus, focusing on the degree of preexisting immunity that may have existed and was boosted by prior encounters with subtype H1N1 viruses

Hemagglutination assay

Pandemic

Cross-reactivity

Serial dilution

10.3201/eid1606.100138

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Microbial and serological effects of vaccination of sows and suckling piglets with an attenuated live Salmonella vaccine

International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork (2011)

Uwe Roesler M. Stief Thomas Lindner Uwe Truyen Hans-Joachim Selbitz

The aim of the study was to investigate the use of the orally applicated attenuated Salmonella vaccine Salmoporc® (which is already licensed for runners and fattening pigs) in three days old suckling piglets. In particular, the tolerance, colonisation kinetics, humoral immune response, protection against challenge infection with Salmonella Typhimurium DT104 and a possible interference of maternal antibodies on the success of vaccination have been investigated.

Attenuated vaccine

10.31274/safepork-180809-595

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Citations (1)

Zoonoserisiken - Aktuelles für die Beratung in der Praxis

kleintier konkret (2008)

Hans-Joachim Selbitz Manfred Moos

In den letzen Jahren haben Tierseuchen eine besondere öffentliche Aufmerksamkeit erfahren. Bilder von in Schutzanzügen gekleideten Personen neben gekeulten Rinderherden oder verendeten Wildvögeln haben sich eingeprägt und werden nicht selten mit einer Bedrohung assoziiert. Dazu kommen Meldungen über lebensmittelbedingte Infektionen, die Dezimierung des Gorillabestandes in Afrika durch das Ebolavirus oder aktuell das Auftreten der Blauzungenkrankheit in Deutschland. Doch wie hoch ist das Risiko tatsächlich?

10.1055/s-2008-1034355

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[Study of the virulence of Actinobacillus pleuropneumoniae in finishing pigs as a basis for vaccination development].

PubMed (2008)

Isabel Hennig‐Pauka Nina Baltes Ilse D. Jacobsen Janin Stratmann-Selke Gerald-Friedrich Gerlach

For vaccine licensing data about efficiency and duration of protection are essential. Within the scope of the developement of a new subunit vaccine against Actinobacillus pleuropneumoniae (A.pp.) the protective efficiency over the whole length of the fattening period must be proven. This required infection experiments in finishing pigs. Eight pigs in the age of six months were infected experimentally into the trachea with an A.pp. serotyp 2 strain. To our knowledge data about the susceptibility of pigs of this age do not exist, so that the infectious dose for pigs of this age and this route of infection had to be determined. Two pigs each were infected with different doses of 10(10), 6 x 10(5), 8 x 10(3) and 2 x 10(3) CFU (colony forming units). The aim of the study was to produce a typical pleuropneumonia with fever and severe respiratory symptoms as well as characteristic pathomorphological lung alterations without loss of animals during the acute stage of infection. The pathogen should be cultivated from lung tissue. The recommended dose for testing the efficiency of vaccines turned out to be approximately 10(3) CFU A.pp. serotyp 2.

Actinobacillus pleuropneumoniae

Pleuropneumonia

Actinobacillus

Colony-forming unit

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Citations (8)

Immunoprophylaxis as a method to help reduce the incidence of Salmonella infection in swine

International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork (2001)

Thomas Lindner Sven Springer G Steinbach Hans-Joachim Selbitz

Swine reared for fattening which were clinically proven to have salmonellosis (S. typhimuriwn) were immunized with a S. typhimurium live vaccine to prevent clinical disease and reduce the level of infection amongst the swine. To assess the outcome of vaccination the ileocaecal lymph nodes of the swine were removed at the time of slaughter and cultures set up to establish the presence of salmonella. In addition, serum samples were taken and assayed for antibodies to S. typhimurium. Use of the vaccine prevented animals from developing clinical disease and resulted in a marked reduction in the isolation of S. typhimurium from the ileocaecal lymph nodes of the swine at slaughter and in the number of animals with high antibody value (≥40 OD%).

10.31274/safepork-180809-1073

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Citations (1)

Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany

Veterinary Microbiology (2013)

Jeannette Lange Marco Groth Michael Schlegel Andi Krumbholz Kerstin Wieczorek

Pandemic

Lineage (genetic)

H5N1 genetic structure

10.1016/j.vetmic.2013.09.024

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Citations (51)

Medizinische Mikrobiologie, Infektions- und Seuchenlehre

A. Mayr Mathias Büttner Brigitte Gedek Oskar‐Rüger Kaaden Monika Krüger

10.1055/b-002-11347

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Citations (3)