Nikos Vogiatzakis

National and Kapodistrian University of Athens

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Danai Veltra

National and Kapodistrian University of Athens

Charalambia Tsaroucha

National and Kapodistrian University of Athens

Joanne Traeger‐Synodinos

National and Kapodistrian University of Athens

Hanns Lochmüller

Children's Hospital of Eastern Ontario

Anastasios Mitrakos

National and Kapodistrian University of Athens

Nicoletta Selenti

National and Kapodistrian University of Athens

Giorgos‐Konstantinos Papadimas

National and Kapodistrian University of Athens

Faidon‐Nikolaos Tilemis

National and Kapodistrian University of Athens

Evangelia Nitsa

National and Kapodistrian University of Athens

Nikolaos M. Marinakis

National and Kapodistrian University of Athens

Cooperative Institutions

National and Kapodistrian University of Athens

Hippocration General Hospital

Ippokrateio General Hospital of Thessaloniki

Children's Hospital Agia Sophia

Athens Medical Center

Eginition Hospital

Aristotle University of Thessaloniki

Georgetown University

Georgetown University Medical Center

Boston Children's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity

Figshare (2023)

Kyriaki Kekou Maria Svingou Nikos Vogiatzakis Evangelia Nitsa Danai Veltra

Persistent hyperCKemia results from muscle dysfunction often attributed to genetic alterations of muscle-related genes, such as the dystrophin gene (DMD). Retrospective assessment of findings from DMD analysis, in association with persistent HyperCKemia, was conducted. Evaluation of medical records from 1354 unrelated cases referred during the period 1996–2021. Assessment of data concerning the detection of DMD gene rearrangements and nucleotide variants. A total of 730 individuals (657 cases, 569 of Greek and 88 of Albanian origins) were identified, allowing an overall estimation of dystrophinopathy incidence at ~1:3800 live male births. The heterogeneous spectrum of 275 distinct DMD alterations comprised exon(s) deletions/duplications, nucleotide variants, and rare events, such as chromosome translocation {t(X;20)}, contiguous gene deletions, and a fused gene involving the DMD and the DOCK8 genes. Ethnic-specific findings include a common founder variant in exon 36 (‘Hellenic’ variant). Some 50% of hyperCKemia cases were characterized as dystrophinopathies, highlighting that DMD variants may be considered the most common cause of hyperCKemia in Greece. Delineation of the broad genetic and clinical heterogeneity is fundamental for actionable public health decisions and theragnosis, as well as the establishment of guidelines addressing ethical considerations, especially related to the mild asymptomatic patient subgroup.

10.6084/m9.figshare.24249711

Cite

Citations (0)

Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study

Journal of Human Hypertension (2018)

Alexandros Kasiakogias Costas Tsioufis Kyriakos Dimitriadis D. Konstantinidis A. Koumelli

Stroke

10.1038/s41371-018-0065-y

Cite

Citations (12)

Successful primary PCI during prolonged continuous cardiopulmonary resuscitation with an automated chest compression device (AutoPulse)

International Journal of Cardiology (2016)

George Latsios Alexios S. Antonopoulos Nikos Vogiatzakis Eleni Melidi N. Koufakis

10.1016/j.ijcard.2016.10.023

Cite

Citations (9)

Effect of renal sympathetic denervation on short-term blood pressure variability in resistant hypertension

Journal of Hypertension (2017)

Nikos Vogiatzakis Costas Tsioufis Georgios Georgiopoulos Costas Thomopoulos Kyriakos Dimitriadis

Background/objectives: Short-term blood pressure variability (BPV) is affected by multiple factors including the sympathetic nervous system drive. Regarding the latter, the novel interventional technology of renal denervation (RDN), by modulating the sympathetic system activation, could have a beneficial impact on BPV. The aim of the current study is to review and meta-analyze the available evidence on the effect of RDN on short-term BPV. Methods: We searched Medline/PubMed database until October 2016 for studies with eligible content. We performed random-effect meta-analyses for 12 outcomes of interest: the standard deviation (SD) of SBP (24 h, daytime and night-time) and DBP (24 h, daytime and night-time), the weighted SD of SBP and DBP across 24 h, the coefficient of variation of SBP and DBP across 24 h and the average real variability of SBP and DBP across 24 h. Results: RDN reduced the SD of SBP across 24 h [mean change: −1.212 (95% confidence intervals (CIs): −2.354/−0.071), P = 0.037] and decreased the SD of systolic daytime BP [mean difference: −1.617 (95% CIs: −3.21/−0.026), P = 0.046] and diastolic daytime BP (marginally) [mean difference: −2.605 (95% CIs: −5.21/−0.003), P = 0.05]. The effect of RDN in reducing SD of SBP across 24 h or DBP across daytime was not influenced by absolute or relative reduction in SBP and DBP indices. (P > 0.1 for all). Conclusion: Catheter-based RDN in resistant hypertensive patients can favorably affect short-term BPV, independent of the level of BP reduction. Further investigation of the effect of RDN on BPV is needed with large randomized trials.

Sympathetic nervous system

Renal sympathetic denervation

10.1097/hjh.0000000000001391

Cite

Citations (12)

Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity

Expert Review of Molecular Diagnostics (2023)

Kyriaki Kekou Maria Svingou Nikos Vogiatzakis Evangelia Nitsa Danai Veltra

Persistent hyperCKemia results from muscle dysfunction often attributed to genetic alterations of muscle-related genes, such as the dystrophin gene (DMD). Retrospective assessment of findings from DMD analysis, in association with persistent HyperCKemia, was conducted.Evaluation of medical records from 1354 unrelated cases referred during the period 1996-2021. Assessment of data concerning the detection of DMD gene rearrangements and nucleotide variants.A total of 730 individuals (657 cases, 569 of Greek and 88 of Albanian origins) were identified, allowing an overall estimation of dystrophinopathy incidence at ~1:3800 live male births. The heterogeneous spectrum of 275 distinct DMD alterations comprised exon(s) deletions/duplications, nucleotide variants, and rare events, such as chromosome translocation {t(X;20)}, contiguous gene deletions, and a fused gene involving the DMD and the DOCK8 genes. Ethnic-specific findings include a common founder variant in exon 36 ('Hellenic' variant).Some 50% of hyperCKemia cases were characterized as dystrophinopathies, highlighting that DMD variants may be considered the most common cause of hyperCKemia in Greece. Delineation of the broad genetic and clinical heterogeneity is fundamental for actionable public health decisions and theragnosis, as well as the establishment of guidelines addressing ethical considerations, especially related to the mild asymptomatic patient subgroup.

Muscle weakness

10.1080/14737159.2023.2264181

Cite

Citations (1)

Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variants’ heterogeneity

Figshare (2023)

Kyriaki Kekou Maria Svingou Nikos Vogiatzakis Evangelia Nitsa Danai Veltra

10.6084/m9.figshare.24249711.v1

Cite

Citations (0)