Alejandro Bayón

Universidad de Murcia

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Floyd E. Bloom

Salk Institute for Biological Studies

Jesús Talavera López

Universidad de Murcia

María Josefa Fernández del Palacio

Universidad de Murcia

Benito Antón

Instituto Nacional de Psiquiatría

Roger Guillemin

Salk Institute for Biological Studies

Jean Rossier

Centre National de la Recherche Scientifique

William J. Shoemaker

Tilburg University

René Drucker‐Colín

Universidad Nacional Autónoma de México

Nicholas Ling

University of Waikato

ÓC

Óscar. Cortadellas

Universidad Cardenal Herrera CEU

Cooperative Institutions

Universidad de Murcia

Universidad Nacional Autónoma de México

Salk Institute for Biological Studies

Instituto Nacional de Psiquiatría

Universitat Autònoma de Barcelona

University of Córdoba

Universidad de Las Palmas de Gran Canaria

Centro de Edafología y Biología Aplicada del Segura

John Wiley & Sons (United States)

Scripps Research Institute

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In vivo perfusion and release of neuroactive substances : methods and strategies

Academic Press eBooks (1985)

Alejandro Bayón René Raúl Drucker‐Colín

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Citations (22)

Characterization of the Actions of Toxins II‐9.2.2 and II‐10 from the Venom of the Scorpion Centruroides noxius on Transmitter Release from Mouse Brain Synaptosomes

Journal of Neurochemistry (1987)

Marı́a Sitges Lourival D. Possani Alejandro Bayón

Abstract: Toxic peptides II‐9.2.2 and II‐10, purified from Centruroides noxius venom, bear highly homologous N‐ter‐minal amino acid sequences, and both toxins are lethal to mice. However, only toxin II‐10 is active on the voltage‐clamped squid axon, selectively decreasing the voltage‐dependent Na + current. Here, we have tested toxins II‐9 and II‐10 on synaptosomes from mouse brain: both toxins increased the release of γ‐[ 3 H]aminobutyric acid ([ 3 H]GABA). Their effect was completely blocked by tetro‐dotoxin or by the absence of external Na + . Also, both toxins increased Na + permeability in isolated nerve terminals. Besides the observation that toxin II‐9 is active on synaptosomes, the effect of toxin II‐10 in this preparation is opposite to that observed in the squid axon. Thus, our results reflect functional differences between the populations of Na + channels in mouse brain synaptosomes and in the squid axon. The release of GABA evoked by these toxins from synaptosomes required external Ca 2+ and was blocked by Ca 2+ channel blockers (verapamil and Co 2+ ). This latter observation is in sharp contrast to the releasing action of veratrine, which evoked release even in the absence of external Ca 2+ . Furthermore, the action of both C. noxius toxins was potentiated by veratrine, a result suggesting they have different mechanisms of action. Among drugs that release neuro‐transmitters by increasing Na + permeability, it is noteworthy that scorpion toxins are the only ones yet reported to have a strict requirement for external Ca 2+ .

Synaptosome

10.1111/j.1471-4159.1987.tb05732.x

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Citations (14)

Systemic Hypertension in Dogs with Leishmaniasis: Prevalence and Clinical Consequences

Journal of Veterinary Internal Medicine (2006)

Óscar. Cortadellas María Josefa Fernández del Palacio Alejandro Bayón Angel Albert Jesús Talavera López

A prospective study was performed (November 1998 to December 2003) to determine the prevalence of systemic hypertension (SH) in dogs with glomerular disease secondary to leishmaniasis. One hundred and five dogs with leishmaniasis were screened and staged for the presence of renal disease (RD) and SH. For the purpose of the study, RD was defined as serum creatinine concentration ≥ 1.4 mg/dL, a urine protein/creatinine ratio ≥ 0.5, or both. SH was defined as a systolic blood pressure (SBP) ≥ 180 mm Hg or an SBP between 150 and 179 mm Hg in the presence of clinical manifestations of SH. Fifty-two (49.5%) of the dogs had some degree of RD, and 32 (61.5%) of these dogs were diagnosed with SH. Moreover, SH also was diagnosed in 3 dogs without RD. Left ventricular hypertrophy (LVH), estimated by echocardiography, was the most frequently observed systemic consequence of hypertension, being present in 32 (91.4%) of the hypertensive dogs. Echocardiographic abnormalities were not detected in any of the 33 dogs with leishmaniasis without RD, which were used as controls. Ocular consequences of SH were observed in only 2 (5.7%) of the dogs with hypertension. We conclude that SH is prevalent in dogs with RD secondary to leishmaniasis, not only in the more severe stages but also in the early course of the illness before azotemia becomes apparent. Canine leishmaniasis may be a useful natural model to study SH secondary to glomerular disease.

Azotemia

Canine leishmaniasis

10.1892/0891-6640(2006)20[941:shidwl]2.0.co;2

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In vivo release of enkephalin from the globus pallidus

Neuroscience Letters (1981)

Alejandro Bayón William J. Shoemaker Lourdes Lugo Raana Azad Nicholas Ling

Putamen

10.1016/0304-3940(81)90360-8

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Citations (30)

Functional Changes of Synapses

Advances in behavioral biology (1974)

Víctor Alemán Alejandro Bayón Jorge Molina

10.1007/978-1-4684-3066-0_7

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Citations (9)

Preface

Elsevier eBooks (1985)

Alejandro Bayón René Drucker‐Colín

10.1016/b978-0-12-083350-4.50005-4

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Sondas de perfusión intracerebral in vivo - un nuevo diseño y su evaluación -

Salud Mental (1988)

Alejandro Bayón Benito Antón Sara Solano Ana María Sierra-Honigmann Monserrat Sordo

A pesar del desarrollo reciente de tecnicas biofisicas para dar imagenes de las funciones del cerebro en el animal integro (v.g tomografia de emision de positrones, resonancia magnetica nuclear), las sondas de perfusion intracerebral son aun el unico medio directo de estudio de los fenomenos neuroquimicos in vivo. Sin embargo, estos instrumentos tradicionales de perfusion, por su naturaleza invasiva y la lesion que producen, reclaman nuevos disenos y mejoras. Hemos redisenado la sonda clasica de perfusion -canula concentrica de infusion y extraccion- modificando la geometria de su punta: La canula de infusion se retrajo hacia adentro de la canula externa (de extraccion) para evitar que hiciera contacto con el tejido y lo erosionara; ademas, para aumentar la interfase de disfusion entre el tejido y el liquido de perfusion, se perforan ranuras en el cuerpo de la canula externa. Esta sonda ranurada elimina practicamente las lesiones accidentales por obstrucciones al flujo y los sangrados durante la perfusion, pero conserva la misma eficiencia de difusion que se obtiene con las sondas tradicionales. La sonda que hemos construido es de geometria identica a la nueva generacion de sondas de dialisis intracerebral y comparte muchas de sus ventajas en cuanto a la proteccion del tejido. Al carecer de la barrera que establece una membrana de dialisis, permite el libre acceso al tejido cerebral. Estas sondas de perfusion, mas seguras y eficientes, pudieran ser aplicadas en la clinica a corto plazo.

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Common Atrium in a Dog

Journal of Veterinary Internal Medicine (2001)

María Josefa Fernández del Palacio Alfonso Costa Jesús Talavera López Alejandro Bayón

Atrium (architecture)

10.1892/0891-6640(2001)015<0057:caiad>2.3.co;2

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Citations (2)

Diurnal rhythm of the in vivo release of enkephalin from the globus pallidus of the rat

Regulatory Peptides (1986)