F. W. Goldstein

Hôpital Paris Saint-Joseph

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J. F. Acar

Sorbonne Université

Jean Carlet

CNR de la Résistance aux Antibiotiques

M Kitzis

Sorbonne Université

Marie-Dominique Kitzis

Hôpital Paris Saint-Joseph

Benoît Misset

University of Liège

Ludwig Gutmann

Centre for the Observation and Modelling of Earthquakes, Volcanoes and Tectonics

Jean‐Luc Mainardi

Université Paris Cité

E. Collatz

Université Paris Cité

Y. Péan

CNR de la Résistance aux Antibiotiques

Jacqu̧es Acar

Sorbonne Université

Cooperative Institutions

Inserm

Hôpital Saint Joseph

Université Paris Cité

Assistance Publique – Hôpitaux de Paris

Centre National de la Recherche Scientifique

Sorbonne Université

Hôpital Paris Saint-Joseph

Institut Pasteur

Université Claude Bernard Lyon 1

Istituti di Ricovero e Cura a Carattere Scientifico

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The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci

Clinical Microbiology and Infection (1997)

Keith P. Klugman F. W. Goldstein Shigeru Kohno Fernando Baquero

Cefpirome

Pneumococcal infections

Viridans streptococci

Cefepime

10.1111/j.1469-0691.1997.tb00646.x

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Citations (44)

Abstracts of posters

Pharmacy World & Science (1994)

L. Suffisseau M. C. Taugourdeau F. W. Goldstein Jean‐Luc Mainardi Ph. Larrouturou

10.1007/bf01876922

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Citations (24)

[Treatment of severe botulism with 3,4-diaminopyridine]].

PubMed (2002)

M Dock Ait Ali A. Karras B Misset Maïté Garrouste-Orgeas

Botulism

Clostridium botulinum

Source

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Citations (21)

Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase inhibitors

Antimicrobial Agents and Chemotherapy (1988)

M Kitzis D Billot-Klein F. W. Goldstein R. Williamson Guy Tran Van Nhieu

The novel beta-lactamase CTX-1 (pI 6.3) encoded on a transferable 84-kilobase plasmid was found in six different bacterial species. It was responsible for a significant decrease in susceptibility towards most penicillins and cephalosporins, except imipenem, temocillin, and cephalosporins which have a 7-alpha-methoxy substituent. Synergy between either ampicillin, piperacillin, cefotaxime, ceftazidime, or aztreonam and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and YTR 830) was generally found for different strains harboring CTX-1. This enzyme may be related to or derived from the TEM enzyme, since an intragenic probe of the TEM-1 gene hybridized with a fragment of the plasmid carrying CTX-1.

Aztreonam

Sulbactam

Beta-lactamase

Beta-Lactamase Inhibitors

Cefoperazone

Moxalactam

10.1128/aac.32.1.9

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Citations (118)

SYN987, SYN1193, and SYN1253, new quinolones highly active against Gram-positive cocci

Journal of Antimicrobial Chemotherapy (1995)

M Kitzis F. W. Goldstein Norihiro Ishida J. F. Acar

SYN987, 1193 and 1253 are new fluorinated quinolones with enhanced activity against Gram-positive bacteria. The MICs of SYN 987, 1193 or 1253 were studied by an agar dilution method against 88 streptococci (including penicillin resistant Streptococcus pneumoniae), 30 enterococci and 62 Staphylococcus aureus. SYN 987, 1193 and 1253 were 2 to 4 times more active than sparfloxacin and 16-64 times more active than older fluoroquinolones against all streptococci and ciprofloxacin-resistant S. aureus. This study demonstrates that SYN 987, 1193 and 1253 are extremely potent antibacterial agents which deserve further evaluation.

Sparfloxacin

Agar dilution

Gram-Positive Cocci

Agar Dilution Method

Gram-Positive Bacteria

10.1093/jac/36.1.209

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Citations (2)

Highlights of the French antimicrobial resistance surveillance project

Diagnostic Microbiology and Infectious Disease (1996)

Y. Péan F. W. Goldstein M.L. Guerrier

10.1016/s0732-8893(96)00137-x

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Citations (9)

Plasmid-Mediated Resistance to Multiple Antibiotics in Salmonella typhi

The Journal of Infectious Diseases (1986)

F. W. Goldstein Jorge Chumpitaz José Guevara Barbara Papadopoulou J. F. Acar

Two hundred forty-one strains of Salmonella typhii isolated in Lima, Peru, from October 1981 through February 1983 were tested for susceptibility to antimicrobial agents. Seventy-two strains (29.9%) were resistant to chloramphenicol and other antibiotics, including ampicillin, sulfonamides, and trimethoprim. The minimal inhibitory concentrations of 17 antimicrobial agents were determined for all of these chloramphenicol-resistant strains. Sch 25393, new beta-lactams, new quinolones, and the formulation clavulanic acid-amoxicillin were effective against all the strains. Four different resistance patterns distributed among eight phage types were observed. The 72 resistant S. typhi could transfer the resistance marker into Escherichia coli C1, and all the plasmids belonged to the incompatibility group H1.

Trimethoprim

10.1093/infdis/153.2.261

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Citations (86)

O capitalismo num beco sem saída e a era da destruição dos empregos: uma visão marxista

Argumentum (2012)

F. W. Goldstein

O objetivo deste trabalho é analisar a crise capitalista atual. O ponto de vista de nossa argumentação é do marxismo revolucionário. O marxismo não tem bola de cristal, ou habilidade de profetizar. Ele conta apenas com a teoria científica do materialismo histórico, observa os eventos o mais cuidadosamente possível, e tenta desvelar os processos de desenvolvimento para intervir, com mais eficácia, nesses eventos, em nome da classe trabalhadora e dos oprimidos.

10.18315/argumentum.v3i2.2206

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Citations (0)

Isolation of Eikenella corrodens from human infections: Report of six cases

Journal of Infection (1980)

Anderson Luiz Pinheiro Maia F. W. Goldstein J. F. Acar F Roland

Eikenella corrodens

Fastidious organism

Isolation

10.1016/s0163-4453(80)92792-9

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Citations (12)

Identification and Phenotypic Characterization of a β-Lactam-Dependent, Methicillin-Resistant Staphylococcus aureus Strain

Antimicrobial Agents and Chemotherapy (2007)

F. W. Goldstein Jiřı́ Perůtka Arabela Cuirolo Konrad Plata Diego Faccone

Methicillin resistance in Staphylococcus aureus is primarily mediated by the acquired penicillin-binding protein PBP 2a, which is encoded by mecA. PBP 2a acts together with native PBP 2 to mediate oxacillin resistance by contributing complementary transpeptidase and transglycosylase activities, respectively. In this study, we have investigated a phenotype of beta-lactam dependence in a clinical methicillin-resistant S. aureus strain (strain 2884D) obtained by in vitro selection with ceftobiprole. 28884D, which grew very poorly in blood agar, required the presence of the beta-lactam antibiotics to grow. On the basis of this observation, we hypothesized that a gene or genes essential for growth were dependent on oxacillin induction. Identification and analysis of genes regulated by oxacillin were performed by both real-time reverse transcription-PCR and spotted microarray analysis. We found that mecA was constitutively expressed in strain 2884D and that the constitutive expression resulted from perturbations in the two systems involved in its regulation, i.e., MecI/MecR1 (staphylococcal chromosome cassette mec type I) and BlaI/BlaR1 (nonfunctional penicillinase operon). PBP 2 appeared to be poorly induced by oxacillin in 2884D. Further analysis of the PBP 2 two-component VraSR regulatory system showed that it was nonfunctional, accounting for the lack of response to oxacillin. Together, these results support the notion that limited PBP 2 availability may have led 2884D to become dependent on oxacillin-mediated mecA induction as a required survival mechanism.

Penicillin binding proteins

SCCmec

10.1128/aac.00040-07

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Citations (22)