F Aguiló

St John of God Hospital Sierra Leone

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N Serrallach

Ajuntament de L’Hospitalet

Carlos Torrecilla

Bellvitge University Hospital

José Francisco Suárez

Bellvitge University Hospital

Eduardo L. Franco

McGill University

Ferràn Guedea

Institut Català d'Oncologia

Enric Condom

Bellvitge University Hospital

Virginia Nunes

Universitat de Barcelona

H. Medrano

Universitat de les Illes Balears

Jesús Abril

Institut d'Investigació Biomédica de Bellvitge

L Haddock

University of Puerto Rico System

Cooperative Institutions

Bellvitge University Hospital

Universitat de Barcelona

Institut Català d'Oncologia

Institut d'Investigació Biomédica de Bellvitge

Duran i Reynals Hospital

Ajuntament de L’Hospitalet

Universitat Autònoma de Barcelona

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Hospital de Sant Pau

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417 Biochemical disease-free and overall survival of treatments for localized prostate cancer: Cohort study with a 7 year follow-up

European Urology Supplements (2014)

Xavier Bonet José Francisco Suárez M. Castells Adela Vicens Eduardo L. Franco

10.1016/s1569-9056(14)60411-5

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Salivary testosterone: its application in the follow-up of hypo- and hyper-androgenic states.

PubMed (1987)

Navarro Ma Villabona Cm F Aguiló José Manuel Rodríguez Rodríguez

To the Editor: Salivary testosterpne levels are a good index for the assessment of the true values of free serum testosterone (l, 2). Nevertheless, the correlation between saliva and serum testosterone levels in the follow-up after the treatment of several clinical situations (3,4) is not well studied. We studied salivary and serum testosterone by an RIA method in: a) 10 women affected by hirsutism, aged 16 to 36 years, treated with ethinyloestradiol and laevonorgestrel during three consecutive months, b) samples from 4 patients, aged 61 to 71 years, affected by prostatic carcinoma and treated with flutamide and leuprolide and one of them with diethylstilboestrol during 2 consecutive days, each for two hours, c) 44 boys aged 7 to 15 years with unl· or bilateral cryptorchidism, who had undergone surgical treatment. The correlations between salivary and serum testosterone levels in these different groups were: hirsute women r = 0.57 (p < 0.01); patients with prostatic carcinoma r = 0.62 (p < 0.001); boys with cryptorchidism r = 0.70 (p < 0.001). Our results show that: 1) in the group affected by hirsutism the use of two dnigs that act through different mechanisms of action, such as hormone transport, can hamper the correlation between both parameters, 2) in the patients affected by prostatic carcinoma, in spite of the use of diethylstilboestrol, can modify the sex hormone binding globulin (SHBG), the correlation fouind was significant, 3) in the cryptorchidism group the better correlation found between salivary and serum testosterone levels can be explained by the absence of medication. Salivary and serum testosterone levels in the follow-up of medical treatment in hypoand hyperandrogenic states must be treated with caution.

Flutamide

hirsutism

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Salivary Testosterone in Prostatic Carcinoma

British Journal of Urology (1989)

Miguel Navarro F Aguiló C Villabona Carlos Torrecilla R Bonnin

Summary— Testosterone concentrations in saliva were measured in 13 patients with prostatic carcinoma after surgical or medical (diethylstilboestrol or Estracyt) orchiectomy. The salivary testosterone values in these patients were significantly lower than in normal males but not significantly different from those in normal females. The salivary testosterone concentrations were measured for 6 consecutive months and did not vary significantly from month to month. The results suggest that the measurement of salivary testosterone concentrations could be useful in evaluating the androgenic function of patients with prostatic carcinoma after medical or surgical orchiectomy.

Orchiectomy

10.1111/j.1464-410x.1989.tb05194.x

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Citations (6)

[Malignant neoplasms and kidney transplantation].

PubMed (1994)

N Serrallach Riera Ll Eduardo L. Franco F Aguiló Javier Naranjo

Immunosuppression

Etiology

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Unusual cases of hyperparathyroidism.

PubMed (1995)

E Vázquez-Quintana L Haddock F Aguiló Ron Sotomayor Martha Ramírez

The history, physical and radiologic findings, treatment and pathology in five unusual cases of hyperparathyroidism is presented. The hyperparathyroidism was caused by a large (113 grams) mediastinal adenoma in the first patient, who is alive 25 years after surgery. A parathyroid carcinoma with compression of the esophagus was documented in the second patient. This patient is alive and normocalcemic 23 years after surgical treatment. A third patient with hyperplasia returned with hypercalcemia 20 years postsurgery requiring reoperation. A fourth patient with advanced bone findings was found to have a parathyroid adenoma. The fifth case is a patient with tertiary hyperparathyroidism secondary to hypophosphatemic rickets.

Tertiary hyperparathyroidism

Parathyroid carcinoma

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127 IMPACT ON HEALTH RELATED QUALITY OF LIFE OF RADICAL PROSTATECTOMY AND PROSTATE BRACHYTHERAPY IN PATIENTS WITH LOW AND INTERMEDIATE-RISK CLINICALLY LOCALIZED PROSTATE CANCER

European Urology Supplements (2007)

José Francisco Suárez F Aguiló Montse Ferrer Ferràn Guedea P. Fernandez

10.1016/s1569-9056(07)60126-2

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Citations (1)

An update on the discovery, pathophysiological actions, clinical manifestations and possible physiology of parathyroid related peptide.

PubMed (1997)

A. Alcántara Montalvo-Figueroa Ja Sheila J. Toro F Aguiló

PTHrP has had an unidentified role in medicine since 1930, when Albright described a patient with renal cortical cell carcinoma with hypercalcemia. Since then hypercalcemia has been recognized as the most common paraneoplastic syndrome. At that time the concept of "ectopic PTH syndrome" was introduced, and remained in literature until the true etiology was finally described. In the early 1970's Roof and Benson presented evidence that PTH in humoral hypercalcemia differed from "authentic" PTH. This marked the starting point for researchers to try identifying the molecule that mimicked PTH action and structure. This molecule, named parathyroid-related peptide, has been associated to hypercalcemia seen with solid tumors, such as squamous cell carcinoma of the lung and renal cortical cell carcinoma. PTHrP has been demonstrated to have similar actions to PTH but to differ in decreasing osteoblastic activity while increasing osteoclastic activity. The more fascinating finding was the presence of the PTHrP genes throughout the body, mostly the lactating breast as well as the heart, lungs and skin among others. Despite its identification, finding its physiological roles on normal tissue still remains to be clarified.

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Prostate brachytherapy technique

European Urology Supplements (2002)

F Aguiló José Francisco Suárez N Serrallach Santiago Arbeláez

Prostate brachytherapy

10.1016/s1569-9056(02)80730-8

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Aneuploidy of chromosome Y in prostate tumors and seminal vesicles: A possible sign of aging rather than an indicator of carcinogenesis?

Molecular Carcinogenesis (2007)

Marga Nadal Guillem Pera Jaume Pujadas Jesús Abril Laura González

Abstract Chromosome Y aneuploidies have been reported as one of the recurrent cytogenetic findings in prostate cancer (PCa) and many other solid and hematological tumors. We have studied this aneuploidy in 28 patients with PCa undergoing radical prostatectomy, one patient with benign hyperplasia (BPH) and four organ donors. A total of 72 samples have been studied: 17 tumors, 25 nontumor prostate tissues, 1 BPH, 21 seminal vesicles samples obtained along with the prostate when patients underwent radical prostatectomy and prostate tissues and seminal vesicles from four organ donors. We have also studied the aneuploidy of chromosome Y in peripheral blood from four of the patients and in seminal vesicles of 11 individuals with bladder cancer (BC). The study has been performed by Fluorescence in situ hybridization (FISH) in uncultured cells. Our results indicate that complete loss of chromosome Y is found in almost all the seminal vesicles both from patients with PCa and patients with BC (samples obtained from the tissue bank), and is more frequent in prostate tumors than in nontumor samples. The percentages of chromosome Y loss in the tissues analyzed are significatively higher than expected in lymphocytes considering the patient's age as reported in the literature. The high percentage of chromosome Y loss found in the nonmalignant seminal vesicles of these patients may be an indicator of an ageing process rather than a primary cytogenetic alteration in the carcinogenesis of the prostate. However, a contribution of this loss to chromosomal instability and therefore, to the multistep tumorigenic process, cannot be discarded. © 2007 Wiley‐Liss, Inc.

Chromosome instability

10.1002/mc.20301

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Citations (16)

Renal Allograft Rupture: Surgical Treatment by Renal Corsetage with Lyophilized Human Dura

The Journal of Urology (1985)

N Serrallach Robert Gutiérrez R. Serrate F Aguiló Juan José Múñoz

No AccessJournal of Urology1 Mar 1985Renal Allograft Rupture: Surgical Treatment by Renal Corsetage with Lyophilized Human Dura N. Serrallach, R. Gutierrez, R. Serrate, F. Aguilò, J. Muñoz, E. Franco, J. Griño, S. Gil-Vernet, J. Alsina, and A. Caralps N. SerrallachN. Serrallach More articles by this author , R. GutierrezR. Gutierrez More articles by this author , R. SerrateR. Serrate More articles by this author , F. AguilòF. Aguilò More articles by this author , J. MuñozJ. Muñoz More articles by this author , E. FrancoE. Franco More articles by this author , J. GriñoJ. Griño More articles by this author , S. Gil-VernetS. Gil-Vernet More articles by this author , J. AlsinaJ. Alsina More articles by this author , and A. CaralpsA. Caralps More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49017-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We report 5 cases of renal allograft rupture in which diagnosis was established early through clinical data, laboratory tests and echography. Immediate surgery confirmed the suspicion in all cases. Acute rejection was present in 4 patients and in 1 the previous surgical puncture from the perirenal collection demonstrated serohematic fluid with a biological character similar to that of lymph. This latter case seemed to confirm the suspicion that any process associated with edema in a kidney with obstructed lymphatic tracts (meticulous lymphatic ligatures during donor extraction) is capable of causing a rupture. Conventional surgical treatment is dangerous and insecure on an edematous and friable kidney, resulting in a nephrectomy rate of 55.7 per cent and a postoperative death rate of 8 per cent. Hematoma evacuation, hemostasis by local compression and tridimensional containment of the ruptured areas should be the principles of this operation. By means of renal corsetage with lyophilized human dura these principles can be achieved. This surgical technique, which is simple and secure, its variations and future possibilities are described. In 3 of our 5 patients corsetage with lyophilized human dura was applied. All 5 grafts have taken. Renal function is good in 3 cases and acceptable in 2 at followup between 2 and 15 months. © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByChopin D, Abbou C, Lottmann H, Popov Z, Lang P, Buisson C, Belghiti D, Colombel M and Auvert J (2018) Conservative Treatment of Renal Allograft Rupture with Polyglactin 910 Mesh and Gelatin Resorcin Formaldehyde GlueJournal of Urology, VOL. 142, NO. 2 Part 1, (363-365), Online publication date: 1-Aug-1989. Volume 133Issue 3March 1985Page: 452-455 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information N. Serrallach More articles by this author R. Gutierrez More articles by this author R. Serrate More articles by this author F. Aguilò More articles by this author J. Muñoz More articles by this author E. Franco More articles by this author J. Griño More articles by this author S. Gil-Vernet More articles by this author J. Alsina More articles by this author A. Caralps More articles by this author Expand All Advertisement Loading ...

10.1016/s0022-5347(17)49017-3

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Citations (11)