Various strains of Streptococcus sanguis adhered to the buccal epithelial cells from both healthy controls and patients with Behçet's disease (BD). Almost all of them strongly adhered to the epithelial cells from patients with BD, whereas smaller numbers of the bacteria were observed on the cells from healthy controls. This phenomenon was especially clear when uncommon serotypes (clinical isolates) were used. Two or more peaks were observed in the distribution of the epithelial cells from patients with BD in the adherence test. In contrast, a single peak was observed in the distribution of the epithelial cells from healthy controls. Cytological differences of the epithelial cells between both groups were not observed in the microscopic image analysis. All the strains of S.sanguis showed agglutination of rabbit erythrocytes, but not agglutination of sheep, horse, swine and duck erythrocytes. Line cell adherence of S.sanguis uncommon serotypes was greater than that of common ones. All strains of S.sanguis showed a reactivity with aggregated human β2-microglobulin, but not with the monomer. The different level of reactivity to aggregated β2-microglobulin was recognised between uncommon and common serotypes. The reaction between aggregated β2-microglobulin and S.sanguis is one of human-bacterium interaction which should be considered in studies of BD.
Journal Article Induction of Glutathione Peroxidase by Linoleic Acid Hydroperoxide in Hansenula mrakii Get access Yoshiharu Inoue, Yoshiharu Inoue Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Takayuki Ichiryu, Takayuki Ichiryu Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Yoshikawa, Koji Yoshikawa Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Linh-Thuoc Tran, Linh-Thuoc Tran Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Kousaku Murata, Kousaku Murata Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Kimura Akira Kimura Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 12, 1 December 1990, Pages 3289–3293, https://doi.org/10.1080/00021369.1990.10870496 Published: 01 December 1990 Article history Received: 06 July 1990 Published: 01 December 1990
We report a rare case of toxoplasmic encephalitis in a non-AIDS patient. A 62-year-old man undergoing hemodialysis for seven months and corticosteroid therapy for rapidly progressive glomerulonephritis and admitted for generalized convulsions was found in cranial magnetic resonance imaging (MRI) to have multiple ring-enhanced lesions. Antibodies against Toxoplasma gondii, and in Sabin-Feldman dye test were extremely high, yielding a diagnosis of toxoplasmic encephalitis. He was also diagnosed as having cytomegaloviral retinitis. Anti-HIV antibody was negative. Treatment with pyrimethamine and clindamycin was effective and intracerebral lesions disappeared. Physicians encounting a similar situation should consider toxoplasmic encephalitis as a differential diagnosis, even in non-HIV patients, and implement confirmational examination.
We studied 93 patients with unclassified uveitis from two regions in Japan (Hokkaido and Kanagawa) to assess the contribution of Borrelia species to this condition. The seroprevalence of antibody to Borrelia species was higher in patients from Hokkaido than in those from Kanagawa. The unclassified uveitis of seropositive patients was probably a complication of Lyme borreliosis since (i) the antibody titers were as high as those in clinically diagnosed Lyme disease patients, (ii) healthy controls from Hokkaido showed low seroprevalence in contrast with unclassified uveitis patients from Hokkaido, and (iii) the reaction pattern of antibodies in sera from patients with unclassified uveitis was the same as that in patients with Lyme disease. This is the first report to reveal the high risk of Lyme borreliosis in patients with unclassified uveitis in regions endemic for Lyme disease. In case of unclassified uveitis as well as in cases of inflammatory disease of unknown origin, Lyme disease should be taken into consideration, especially in regions in which Lyme diseases is endemic, even if it is reported only in animals.
